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Substance Name: Dipivefrin hydrochloride [USP:JAN]
RN: 64019-93-8
UNII: 5QTH9UHV0K
InChIKey: VKFAUCPBMAGVRG-UHFFFAOYSA-N

Classification Codes

  • Antiglaucoma Agent
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H29-N-O5.Cl-H

Molecular Weight

  • 387.901
 
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Names and Synonyms

Name of Substance

  • Dipivefrin
  • Dipivefrin hydrochloride [USP:JAN]

Synonyms

  • (+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate hydrochloride
  • Akpro
  • Dipivalyl epinephrine hydrochloride
  • Dipivefrin HCl
  • Dipivefrin hydrochloride
  • Dipivefrine hydrochloride
  • EINECS 264-609-5
  • Propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, hydrochloride, (+-)-
  • Propine
  • UNII-5QTH9UHV0K

Systematic Names

  • (1)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylene dipivalate hydrochloride
  • Propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, hydrochloride, (+-)-

Registry Numbers

CAS Registry Number

  • 64019-93-8

FDA UNII

  • 5QTH9UHV0K

System Generated Number

  • 0064019938

Molecular Formulas

Molecular Formula

  • C19-H29-N-O5.Cl-H

Molecular Formula Fragments

  • C19-H29-N-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C19H29NO5.ClH/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6;/h8-10,13,20-21H,11H2,1-7H3;1H

InChIKey

VKFAUCPBMAGVRG-UHFFFAOYSA-N

Smiles

Cl.CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 32700ug/kg (32.7mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 25, 1986.
mouse LD50 intravenous 4mg/kg (4mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 25, 1986.
mouse LD50 oral 224mg/kg (224mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 25, 1986.
mouse LD50 subcutaneous 35mg/kg (35mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 25, 1986.
rat LD50 intraperitoneal 8500ug/kg (8.5mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 25, 1986.
rat LD50 oral 183mg/kg (183mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 25, 1986.
rat LD50 subcutaneous 21200ug/kg (21.2mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 25, 1986.