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Substance Name: Pentazocine hydrochloride [USAN:USP]
RN: 64024-15-3
UNII: A36BXO4PPX
InChIKey: OQGYMIIFOSJQSF-NMVCJIEOSA-N

Note

  • The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)

Molecular Formula

  • C19-H27-N-O.Cl-H

Molecular Weight

  • 321.8892
 

Classification Code

  • Analgesic
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Names and Synonyms

Name of Substance

  • Pentazocine hydrochloride [USAN:USP]

Synonyms

  • (+-)-Pentazocine hydrochloride
  • (2R*,6R*,11R*)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
  • EINECS 264-612-1
  • Pentazocine HCl
  • Pentazocine hydrochloride
  • Talwin
  • Talwin (as hydrochloride)
  • Talwin 50
  • UNII-A36BXO4PPX

Systematic Names

  • (2alpha,6alpha,11R*)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
  • 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, hydrochloride, (2alpha,6alpha,11R*)-
  • 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, hydrochloride, (2R,6R,11R)-rel-

Mixture Name

  • Talacen

Registry Numbers

CAS Registry Number

  • 64024-15-3

FDA UNII

  • A36BXO4PPX

Other Registry Number

  • 68964-90-9

Related Registry Number

  • 359-83-1 (Parent)

System Generated Number

  • 0064024153

Molecular Formulas

Molecular Formula

  • C19-H27-N-O.Cl-H

Molecular Formula Fragments

  • C19-H27-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H27NO.ClH/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19;/h5-7,12,14,18,21H,8-11H2,1-4H3;1H/t14-,18+,19+;/m1./s1

InChIKey

OQGYMIIFOSJQSF-NMVCJIEOSA-N

Smiles

Cl.C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CC=C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 151mg/kg (151mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 12, Pg. 39, 1974.
mouse LD50 oral 344mg/kg (344mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 214, 1998.
mouse LD50 subcutaneous 126mg/kg (126mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 43, Pg. 153, 1991.
rat LD50 oral 1217mg/kg (1217mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 214, 1998.
women TDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Israel Journal of Medical Sciences. Vol. 22, Pg. 385, 1986.