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Substance Name: Apocodeine
RN: 641-36-1
UNII: OBF8X37Y5W
InChIKey: DZUOQMBJJSBONO-CQSZACIVSA-N

Note

  • Monomethyl ether of apomorphine; used as expectorant, hypnotic, & cathartic.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H19-N-O2

Molecular Weight

  • 281.353
 
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Names and Synonyms

Name of Substance

  • Apocodeine

Synonyms

  • 5-21-05-00334 (Beilstein Handbook Reference)
  • Apocodein
  • Apocodeine
  • BRN 0032938
  • UNII-OBF8X37Y5W

Systematic Names

  • 4H-Dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-10-methoxy-6-methyl-, (R)- (9CI)
  • 6a-beta-Aporphin-11-ol, 10-methoxy-

Registry Numbers

CAS Registry Number

  • 641-36-1

FDA UNII

  • OBF8X37Y5W

System Generated Number

  • 0000641361

Structure Descriptors

InChI

1S/C18H19NO2/c1-19-9-8-11-4-3-5-13-16(11)14(19)10-12-6-7-15(21-2)18(20)17(12)13/h3-7,14,20H,8-10H2,1-2H3/t14-/m1/s1

InChIKey

DZUOQMBJJSBONO-CQSZACIVSA-N

Smiles

c12c3c4c(ccc(c4O)OC)C[C@H]1[N@@](CCc2ccc3)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 15mg/kg (15mg/kg)   "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 589, 1948.
mouse LDLo subcutaneous 150mg/kg (150mg/kg)   "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 589, 1948.
rabbit LDLo intravenous 25mg/kg (25mg/kg)   "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 589, 1948.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 123.5 deg C   EXP
log P (octanol-water) 3.090 (none)   EST
Atmospheric OH Rate Constant 1.65E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.