Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Cloxacillin Sodium
RN: 642-78-4
UNII: MWQ645MKMF
InChIKey: SCLZRKVZRBKZCR-SLINCCQESA-M

Note

  • A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H18-Cl-N3-O5-S.Na

Molecular Weight

  • 457.8683
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Results Name

  • Cloxacillin sodium

Name of Substance

  • Cloxacillin sodium anhydrous

Synonyms

  • 3-o-Chlorophenyl-5-methyl-4-isoxazolylpenicillin sodium
  • Ankerbin
  • Austrastaph
  • BRL 1621 sodium salt
  • BRL-1621 sodium salt
  • Cloxacillin sodium
  • Cloxapen
  • EINECS 211-390-9
  • Ekvacillin
  • Gelstaph
  • Monosodium cloxacillin
  • Orbenin sodium
  • Prevencilina P
  • Prostaphilin A
  • Prostaphlin A
  • Sodium 3-(o-chlorophenyl)-5-methyl-4-isoxazolylpenicillin
  • Sodium cloxacillin
  • Sodium orbenin
  • Sodium syntarpen
  • Staphybiotic
  • Syntarpen sodium salt
  • Tegopen
  • UNII-MWQ645MKMF

Systematic Names

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, monosodium salt, (2S-(2alpha,5alpha,6beta))-
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, monosodium salt
  • Cloxacillin sodium

Registry Numbers

CAS Registry Number

  • 642-78-4

FDA UNII

  • MWQ645MKMF

Other Registry Numbers

  • 1252-37-5
  • 50794-85-9

System Generated Number

  • 0000642784

Molecular Formulas

Molecular Formula

  • C19-H18-Cl-N3-O5-S.Na

Molecular Formula Fragments

  • C19-H18-Cl-N3-O5-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1

InChIKey

SCLZRKVZRBKZCR-SLINCCQESA-M

Smiles

Cc1c(c(no1)c2ccccc2Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 1117mg/kg (1117mg/kg)   Drugs in Japan Vol. -, Pg. 401, 1995.
mouse LD50 intraperitoneal 1170mg/kg (1170mg/kg)   Drugs in Japan Vol. 6, Pg. 232, 1982.
mouse LD50 intravenous 916mg/kg (916mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 31, Pg. 232, 1968.
mouse LD50 oral 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 232, 1982.
mouse LD50 subcutaneous 1500mg/kg (1500mg/kg)   Drugs in Japan Vol. 6, Pg. 232, 1982.
rat LD50 intraperitoneal 1350mg/kg (1350mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 322, 1965.
rat LD50 intravenous 1660mg/kg (1660mg/kg)   Drugs in Japan Vol. 6, Pg. 232, 1982.
rat LD50 oral 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 232, 1982.
rat LD50 subcutaneous 4200mg/kg (4200mg/kg)   Drugs in Japan Vol. 6, Pg. 232, 1982.