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Substance Name: Oxiconazole nitrate [USAN:JAN]
RN: 64211-46-7
UNII: RQ8UL4C17S
InChIKey: WVNOAGNOIPTWPT-NDUABGMUSA-N

Classification Codes

  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H13-Cl4-N3-O.H-N-O3

Molecular Weight

  • 492.1446
 
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Names and Synonyms

Name of Substance

  • Oxiconazole
  • Oxiconazole nitrate [USAN:JAN]

Synonyms

  • 2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-(o-(2,4-dichlorobenzyl))oxime nitrate
  • 2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-(O-(2,4-dichlorobenzyl)oxime), mononitrate
  • EINECS 264-730-3
  • Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime, (Z)-, mononitrate
  • Myfungar
  • NSC 758958
  • Oceral
  • Oxiconazole mono-nitrate (Z)-isomer
  • Oxiconazole nitrate
  • Oxistat
  • Ro 13-8996
  • Sgd 301-76
  • ST 813
  • ST-813
  • UNII-RQ8UL4C17S

Systematic Names

  • (Z)-1-(2-(2,4-Dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1H-imidazole mononitrate
  • Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime, (Z)-, mononitrate
  • Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, o-((2,4-dichlorophenyl)methyl)oxime, nitrate, (Z)-

Registry Numbers

CAS Registry Number

  • 64211-46-7

FDA UNII

  • RQ8UL4C17S

Other Registry Number

  • 104360-36-3

Related Registry Number

  • 64211-45-6 (parent)

System Generated Number

  • 0064211467

Molecular Formulas

Molecular Formula

  • C18-H13-Cl4-N3-O.H-N-O3

Molecular Formula Fragments

  • C18-H13-Cl4-N3-O
  • COMPONENT
  • H-N-O3

Structure Descriptors

InChI

InChI=1S/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+;

InChIKey

WVNOAGNOIPTWPT-NDUABGMUSA-N

Smiles

O[N+](=O)[O-].Clc1ccc(CO\N=C(/Cn2ccnc2)\c3ccc(Cl)cc3Cl)c(Cl)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 595mg/kg (595mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
mouse LD50 oral 2630mg/kg (2630mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
mouse LDLo subcutaneous > 15gm/kg (15000mg/kg)   Drugs in Japan Vol. -, Pg. 227, 1990.
rat LD50 intraperitoneal 630mg/kg (630mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
rat LD50 oral 2458mg/kg (2458mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 29, Pg. 269, 1998.
rat LDLo subcutaneous > 7500mg/kg (7500mg/kg)   Drugs in Japan Vol. -, Pg. 227, 1990.