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Substance Name: Oltipraz [INN]
RN: 64224-21-1
UNII: 6N510JUL1Y
InChIKey: CKNAQFVBEHDJQV-UHFFFAOYSA-N

Molecular Formula

  • C8-H6-N2-S3

Molecular Weight

  • 226.347
 

Classification Codes

  • Anthelmintics
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Antiparasitic Agents
  • Antiplatyhelmintic Agents
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Mutation Data
  • Nucleic Acid Synthesis Inhibitors
  • Protective Agents
  • Reverse Transcriptase Inhibitors
  • Schistosomicides
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Names and Synonyms

Name of Substance

  • Oltipraz
  • Oltipraz [INN]

Synonyms

  • 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
  • 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione
  • BRN 0978110
  • CCRIS 4048
  • EINECS 264-736-6
  • NSC 347901
  • Oltipraz
  • Oltiprazum
  • Oltiprazum [INN-Latin]
  • RP 35972
  • RP-35,972
  • UNII-6N510JUL1Y

Systematic Names

  • 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-
  • 4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thione
  • Oltipraz

Registry Numbers

CAS Registry Number

  • 64224-21-1

FDA UNII

  • 6N510JUL1Y

System Generated Number

  • 0064224211

Structure Descriptors

InChI

1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3

InChIKey

CKNAQFVBEHDJQV-UHFFFAOYSA-N

Smiles

c1(c2cnccn2)c(c(=S)ss1)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 50mg/kg (50mg/kg)   Drugs of the Future. Vol. 5, Pg. 359, 1980.
man TDLo oral 43mg/kg/D (43mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Drugs of the Future. Vol. 5, Pg. 359, 1980.
monkey LD oral > 100mg/kg (100mg/kg)   Drugs of the Future. Vol. 5, Pg. 359, 1980.
mouse LD50 oral > 5gm/kg (5000mg/kg)   "Current Chemotherapy, Proceedings of the 10th International Congress of Chemotherapy, Zurich 1977," Siegenthaler, W., and R. Luethy, eds., 2 vols., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 148, 1978.