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Substance Name: Meclofenamic acid [USAN:INN:BAN]
RN: 644-62-2
UNII: 48I5LU4ZWD
InChIKey: SBDNJUWAMKYJOX-UHFFFAOYSA-N

Note

  • A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Molecular Formula

  • C14-H11-Cl2-N-O2

Molecular Weight

  • 296.1519
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents

Names and Synonyms

Name of Substance

  • Meclofenamic acid
  • Meclofenamic acid [USAN:INN:BAN]

MeSH Heading

  • Meclofenamic acid

Synonyms

  • 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid
  • Acide meclofenamique
  • Acide meclofenamique [INN-French]
  • Acido meclofenamico
  • Acido meclofenamico [INN-Spanish]
  • Acidum meclofenamicum
  • Acidum meclofenamicum [INN-Latin]
  • Arquel
  • Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-
  • BRN 2221428
  • CCRIS 5532
  • CI-583
  • EINECS 211-419-5
  • INF 4668
  • Meclofenamate
  • Meclofenamic acid
  • Meclomen (free acid)
  • Meclophenamic acid
  • N-(2,6-Dichloro-3-methylphenyl)anthranilic acid
  • N-(2,6-Dichloro-m-tolyl)anthranilic acid
  • N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid
  • NSC 95309
  • UNII-48I5LU4ZWD

Systematic Names

  • Anthranilic acid, N-(2,6-dichloro-m-tolyl)-
  • Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-
  • Meclofenamate
  • Meclofenamic acid

Registry Numbers

CAS Registry Number

  • 644-62-2

FDA UNII

  • 48I5LU4ZWD

System Generated Number

  • 0000644622

Structure Descriptors

InChI

1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)

InChIKey

SBDNJUWAMKYJOX-UHFFFAOYSA-N

Smiles

c1c(c(ccc1)Nc1c(c(ccc1Cl)C)Cl)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intraperitoneal 109mg/kg (109mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 148, Pg. 422, 1965.
rat LD50 oral 100mg/kg (100mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 7, Pg. 481, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 257 deg C   EXP
log P (octanol-water) 6.020 (none)   EST
Water Solubility 30 mg/L   EXP
Atmospheric OH Rate Constant 8.75E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.