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Substance Name: Meclofenamic acid [USAN:INN:BAN]
RN: 644-62-2
UNII: 48I5LU4ZWD
InChIKey: SBDNJUWAMKYJOX-UHFFFAOYSA-N
Note
- A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Molecular Formula
- C14-H11-Cl2-N-O2
Molecular Weight
- 296.1519
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- Classifications
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- Registry Numbers
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- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Cyclooxygenase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Meclofenamic acid
- Meclofenamic acid [USAN:INN:BAN]
MeSH Heading
- Meclofenamic acid
Synonyms
- 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid
- Acide meclofenamique
- Acide meclofenamique [INN-French]
- Acido meclofenamico
- Acido meclofenamico [INN-Spanish]
- Acidum meclofenamicum
- Acidum meclofenamicum [INN-Latin]
- Arquel
- Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-
- BRN 2221428
- CCRIS 5532
- CI-583
- EINECS 211-419-5
- INF 4668
- Meclofenamate
- Meclofenamic acid
- Meclomen (free acid)
- Meclophenamic acid
- N-(2,6-Dichloro-3-methylphenyl)anthranilic acid
- N-(2,6-Dichloro-m-tolyl)anthranilic acid
- N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid
- NSC 95309
- UNII-48I5LU4ZWD
Systematic Names
- Anthranilic acid, N-(2,6-dichloro-m-tolyl)-
- Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-
- Meclofenamate
- Meclofenamic acid
Registry Numbers
CAS Registry Number
- 644-62-2
FDA UNII
- 48I5LU4ZWD
System Generated Number
- 0000644622
Structure Descriptors
InChI
InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)InChIKey
SBDNJUWAMKYJOX-UHFFFAOYSA-NSmiles
Cc1ccc(Cl)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intraperitoneal | 109mg/kg (109mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 148, Pg. 422, 1965. | |
| rat | LD50 | oral | 100mg/kg (100mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 7, Pg. 481, 1977. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 257 | deg C | EXP | |
| log P (octanol-water) | 6.020 | (none) | EST | |
| Water Solubility | 30 | mg/L | EXP | |
| Atmospheric OH Rate Constant | 8.75E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.