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Substance Name: Tizanidine hydrochloride [USAN:USP:JAN]
RN: 64461-82-1
UNII: B53E3NMY5C
InChIKey: ZWUKMNZJRDGCTQ-UHFFFAOYSA-N

Classification Codes

  • Antispasmodic
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C9-H8-Cl-N5-S.Cl-H

Molecular Weight

  • 290.1771
 

Names and Synonyms

Name of Substance

  • Tizanidine hydrochloride [USAN:USP:JAN]

Synonyms

  • 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole hydrochloride
  • 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole monohydrochloride
  • AN021
  • DS 103-282
  • Tizanidine HCl
  • Tizanidine hydrochloride
  • UNII-B53E3NMY5C
  • Zanaflex

Systematic Name

  • 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 64461-82-1

FDA UNII

  • B53E3NMY5C

Related Registry Number

  • 51322-75-9 (Parent)

System Generated Number

  • 0064461821

Molecular Formulas

Molecular Formula

  • C9-H8-Cl-N5-S.Cl-H

Molecular Formula Fragments

  • C9-H8-Cl-N5-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H

InChIKey

ZWUKMNZJRDGCTQ-UHFFFAOYSA-N

Smiles

Cl.c12c(NC3=NCCN3)c(ccc1nsn2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 48mg/kg (48mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse LD50 oral 235mg/kg (235mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #81-02912,
rabbit LD50 oral 98mg/kg (98mg/kg)   Drugs in Japan Vol. -, Pg. 642, 1990.
rat LD50 intravenous 35mg/kg (35mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5811, 1985.
rat LD50 oral 414mg/kg (414mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5811, 1985.
rat LD50 subcutaneous 282mg/kg (282mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5811, 1985.