Skip Navigation
ChemIDplus LiteBrowseAdvanced

Substance Name: Cefotaxime sodium [USAN:USP:JAN]
RN: 64485-93-4
UNII: 258J72S7TZ
InChIKey: AZZMGZXNTDTSME-JUZDKLSSSA-M

Notes

  • Semisynthetic broad-spectrum cephalosporin proposed for Pseudomonas infections.
  • Semisynthetic broad-spectrum cephalosporin.

Molecular Formulas

  • C16-H16-N5-Na-O7-S2
  • C16-H16-N5-O7-S2.Na
  • C16-H17-N5-O7-S2.Na

Molecular Weight

  • 477.4524
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Cefotaxime sodium [USAN:USP:JAN]

MeSH Heading

  • Cefotaxime

Synonyms

  • (+)-Cefotaxime sodium salt
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-
  • Cefotaxime
  • Cefotaxime and dextrose 2.4% in plastic container
  • Cefotaxime and dextrose 3.9% in plastic container
  • Cefotaxime sodium
  • Cefotaxime sodium salt (syn-isomer)
  • Claforan
  • Claforan in dextrose 5% in plastic container
  • Claforan in sodium chloride 0.9% in plastic container
  • Claforan sodium
  • EINECS 264-915-9
  • HR 756
  • Pretor
  • Ralopar
  • RU 24756
  • Sodium (6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate 7(sup 2)-(Z)-(O-methyloxime), acetate (ester)
  • Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
  • Sodium cefotaxime
  • Tolycar
  • Tolycor
  • UNII-258J72S7TZ
  • Zariviz

Systematic Names

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-
  • Sodium (6R-(6alpha,7beta(Z)))-3-(acetoxymethyl)-7-((2-aminothiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

Registry Numbers

CAS Registry Number

  • 64485-93-4

FDA UNII

  • 258J72S7TZ

Related Registry Number

  • 63527-52-6 (Parent)

System Generated Number

  • 0064485934

Molecular Formulas

Molecular Formulas

  • C16-H16-N5-Na-O7-S2
  • C16-H16-N5-O7-S2.Na
  • C16-H17-N5-O7-S2.Na

Molecular Formula Fragments

  • C16-H16-N5-O7-S2
  • C16-H17-N5-O7-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

InChIKey

AZZMGZXNTDTSME-JUZDKLSSSA-M

Smiles

[Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)[O-])COC(=O)C)\c3csc(N)n3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 1800mg/kg/18D (1800mg/kg) BLOOD: AGRANULOCYTOSIS Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 739, 1983.
dog LD50 intramuscular > 716mg/kg (716mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
dog LD50 intravenous > 1500mg/kg (1500mg/kg)   Journal of Antimicrobial Chemotherapy. Vol. 6(Suppl,
mouse LD50 intraperitoneal 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-8, 1982.
mouse LD50 intravenous 6845mg/kg (6845mg/kg)   Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(5), Pg. 25, 1990.
mouse LD50 oral > 20gm/kg (20000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Chemotherapy Vol. 28(Suppl,
mouse LD50 subcutaneous 12950mg/kg (12950mg/kg)   Drugs in Japan Vol. 6, Pg. APP-8, 1982.
rabbit LD50 intravenous 1880mg/kg (1880mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Chemotherapy Vol. 28(Suppl,
rat LD50 intramuscular > 2gm/kg (2000mg/kg)   Chemotherapy Vol. 28(Suppl,
rat LD50 intraperitoneal 10gm/kg (10000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Chemotherapy Vol. 28(Suppl,
rat LD50 intravenous 7gm/kg (7000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-8, 1982.
rat LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Chemotherapy Vol. 28(Suppl,
rat LD50 subcutaneous 18400mg/kg (18400mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Chemotherapy Vol. 28(Suppl,