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Substance Name: Tolmetin sodium [USAN:USP:JAN]
RN: 64490-92-2
UNII: 02N1TZF99F
InChIKey: QQILXENAYPUNEA-UHFFFAOYSA-M

Classification Codes

  • Anti-Inflammatory
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formulas

  • C15-H14-N-Na-O3.2H2-O
  • C15-H14-N-O3.Na.2H2-O

Molecular Weight

  • 315.2992
 
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Names and Synonyms

Name of Substance

  • Tolmetin sodium [USAN:USP:JAN]

Synonyms

  • McN-2559-21-98
  • Sodium 1-methyl-5-p-toluoylpyrrole-2-acetate dihydrate
  • Sodium tolmetin dihydrate
  • Tolectin
  • Tolmetin sodium
  • Tolmetin sodium dihydrate
  • Tolumetin sodium dihydrate
  • UNII-02N1TZF99F

Systematic Name

  • 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate

Registry Numbers

CAS Registry Number

  • 64490-92-2

FDA UNII

  • 02N1TZF99F

Related Registry Number

  • 26171-23-3 (Parent)

System Generated Number

  • 0064490922

Molecular Formulas

Molecular Formulas

  • C15-H14-N-Na-O3.2H2-O
  • C15-H14-N-O3.Na.2H2-O

Molecular Formula Fragments

  • C15-H14-N-Na-O3
  • C15-H14-N-O3
  • COMPONENT
  • H2-O
  • Na

Structure Descriptors

InChI

1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1

InChIKey

QQILXENAYPUNEA-UHFFFAOYSA-M

Smiles

Cc1ccc(cc1)C(=O)c2ccc(n2C)CC(=O)[O-].O.O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 550mg/kg (550mg/kg)   European Patent Application. Vol. #134763,
mouse LD50 intravenous > 622mg/kg (622mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.
mouse LD50 oral 899mg/kg (899mg/kg)   European Patent Application. Vol. #134763,
mouse LD50 subcutaneous 670mg/kg (670mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.
rat LD50 intraperitoneal 612mg/kg (612mg/kg)   European Patent Application. Vol. #134763,
rat LD50 intravenous > 724mg/kg (724mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.
rat LD50 oral 914mg/kg (914mg/kg)   European Patent Application. Vol. #134763,
rat LD50 subcutaneous 1050mg/kg (1050mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.