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Substance Name: Altretamine [USAN:USP:INN:BAN]
RN: 645-05-6
UNII: Q8BIH59O7H
InChIKey: UUVWYPNAQBNQJQ-UHFFFAOYSA-N

Note

  • A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.

Molecular Formula

  • C9-H18-N6

Molecular Weight

  • 210.2832
 

Classification Codes

  • Agricultural Chemical
  • Alkylating Agents
  • Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Drug / Therapeutic Agent
  • Human Data
  • Insect Attractant, Repellent and Chemosterilant
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • Altretamine
  • Altretamine [USAN:USP:INN:BAN]

MeSH Heading

  • Altretamine

Synonyms

  • 1,3,5-Triazine-2,4,6-triamine, N,N,N',N',N',N'-hexamethyl-
  • 2,4,6-Tris(dimethylamino)-1,3,5-triazine
  • 2,4,6-Tris(dimethylamino)-s-triazine
  • 4-26-00-01256 (Beilstein Handbook Reference)
  • AI3-50852
  • Altretamina
  • Altretamina [INN-Spanish]
  • Altretamine
  • Altretaminum
  • Altretaminum [INN-Latin]
  • BRN 0195058
  • CCRIS 5492
  • EINECS 211-428-4
  • ENT 50852
  • Hemel
  • Hexalen [Antineoplastic]
  • Hexamethylmelamine
  • Hexastat
  • HMM
  • HSDB 7559
  • HTM
  • HXM
  • Melamine, hexamethyl-
  • NC 195
  • NCI-C50259
  • NSC 13875
  • s-Triazine, 2,4,6-tris(dimethylamino)-
  • UNII-Q8BIH59O7H

Systematic Names

  • 1,3,5-Triazine-2,4,6-triamine, N,N,N',N',N'',N''-hexamethyl-
  • Altretamine
  • Hexamethylmelamine
  • Melamine, hexamethyl-

Superlist Name

  • Altretamine

Registry Numbers

CAS Registry Number

  • 645-05-6

FDA UNII

  • Q8BIH59O7H

System Generated Number

  • 0000645056

Structure Descriptors

InChI

1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3

InChIKey

UUVWYPNAQBNQJQ-UHFFFAOYSA-N

Smiles

c1(nc(nc(n1)N(C)C)N(C)C)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 341mg/kg (341mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 16, Pg. 100, 1970.
dog LDLo intravenous 100mg/kg (100mg/kg) BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
National Technical Information Service. Vol. PB293-046,
guinea pig LD50 oral 255mg/kg (255mg/kg)   "Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
human TDLo oral 8mg/kg (8mg/kg) BLOOD: LEUKOPENIA

GASTROINTESTINAL: NAUSEA OR VOMITING
Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 505, 1972.
mouse LD10 intraperitoneal 200mg/kg (200mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

BLOOD: GRANULOCYTOPENIA
Cancer Research. Vol. 40, Pg. 2762, 1980.
mouse LD50 intravenous 171mg/kg (171mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
National Technical Information Service. Vol. PB293-046,
mouse LD50 oral 437mg/kg (437mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

BLOOD: HEMORRHAGE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 160, Pg. 83, 1966.
rat LD50 intraperitoneal 265mg/kg (265mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
rat LD50 oral 350mg/kg (350mg/kg)   "Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 172-174 deg C   EXP
log P (octanol-water) 2.73 (none)   EXP
Water Solubility 91 mg/L 25 EXP
Vapor Pressure 2.95E-04 mm Hg 25 EST
Henry's Law Constant 1.72E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.25E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.