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Substance Name: Guanethidine monosulfate [USAN:USP]
RN: 645-43-2
UNII: 5UBY8Y002G
InChIKey: YUFWAVFNITUSHI-UHFFFAOYSA-N

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Skin / Eye Irritant

Molecular Formula

  • C10-H22-N4.H2-O4-S

Molecular Weight

  • 296.3896
 
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Names and Synonyms

Name of Substance

  • Guanethidine monosulfate [USAN:USP]

Synonyms

  • (2-(Hexahydro-1(2H)-azocinyl)ethyl) guanidine hydrogen sulfate
  • (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (1:1)
  • 2-(Octahydro-1-azocinyl)ethyl guanidine sulphate
  • EINECS 211-442-0
  • Guanethidine monosulfate
  • Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (1:1)
  • Ismelin
  • Ismelin sulfate
  • N-(2-Guanidino ethyl)heptamethylenimine sulfate
  • UNII-5UBY8Y002G

Systematic Names

  • (2-(Hexahydro-(2H)-azocin-1-yl)ethyl)guanidinium sulphate
  • Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (1:1)

Mixture Name

  • Esimil

Registry Numbers

CAS Registry Number

  • 645-43-2

FDA UNII

  • 5UBY8Y002G

Related Registry Number

  • 55-65-2 (Parent)

System Generated Number

  • 0000645432

Molecular Formulas

Molecular Formula

  • C10-H22-N4.H2-O4-S

Molecular Formula Fragments

  • C10-H22-N4
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)

InChIKey

YUFWAVFNITUSHI-UHFFFAOYSA-N

Smiles

C1CCCN(CCC1)CCNC(=N)N.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 180mg/kg (180mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 353, 1972.
mouse LD50 intravenous 18500ug/kg (18.5mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 353, 1972.
mouse LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archiv der Pharmazie Vol. 321, Pg. 57, 1988.