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Substance Name: Oxprenolol hydrochloride [USAN:USP:JAN]
RN: 6452-73-9
UNII: F4XSI7SNIU
InChIKey: COAJXCLTPGGDAJ-UHFFFAOYSA-N

Note

  • A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.

Molecular Formula

  • C15-H23-N-O3.Cl-H

Molecular Weight

  • 301.812
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
  • Vasodilator (Coronary)
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Names and Synonyms

Name of Substance

  • Oxprenolol hydrochloride [USAN:USP:JAN]

Synonyms

  • 1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propanol hydrochloride
  • 2-(o-Allyloxyphenoxy)-2-hydroxy-N-isopropyl-1-propylamine hydrochloride
  • 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyloxy)phenoxy)-, hydrochloride
  • Ba 39089
  • Ba-39,089
  • Ba-39089
  • C-39089-Ba
  • CCRIS 1097
  • Ciba 39089Ba
  • Coretal
  • Dialicor
  • Drospfta;ome
  • EINECS 229-260-5
  • Evinrozit
  • Flecor
  • Oxprenolol HCl
  • Oxprenolol hydrochloride
  • Ranidrox
  • Rixiprol
  • Secondafil
  • Slow-Trasicor
  • Trasicor
  • Trepress
  • UNII-F4XSI7SNIU
  • Vrachor

Systematic Names

  • 2-Propanol, 1-(o-allyloxyphenoxy)-3-isopropylamino-, hydrochloride
  • Oxprenolol hydrochloride

Registry Numbers

CAS Registry Number

  • 6452-73-9

FDA UNII

  • F4XSI7SNIU

Related Registry Number

  • 6452-71-7 (Parent)

System Generated Number

  • 0006452739

Molecular Formulas

Molecular Formula

  • C15-H23-N-O3.Cl-H

Molecular Formula Fragments

  • C15-H23-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H23NO3.ClH/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3;/h4-8,12-13,16-17H,1,9-11H2,2-3H3;1H

InChIKey

COAJXCLTPGGDAJ-UHFFFAOYSA-N

Smiles

c1cc(c(cc1)OCC=C)OC[C@@H](O)CNC(C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD90 oral 200mg/kg (200mg/kg) CARDIAC: PULSE RATE

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
dog LD50 intravenous 15mg/kg (15mg/kg) BEHAVIORAL: TREMOR

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1890, 1970.
dog LDLo oral > 30mg/kg (30mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
dog LDLo subcutaneous > 30mg/kg (30mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
mouse LD50 intraperitoneal 170mg/kg (170mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SLEEP
Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 151, 1973.
mouse LD50 intravenous 20mg/kg (20mg/kg) AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
mouse LD50 oral 520mg/kg (520mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3131, 1973.
mouse LD50 subcutaneous 245mg/kg (245mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
rabbit LDLo intravenous 20mg/kg (20mg/kg) BEHAVIORAL: ATAXIA

CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1890, 1970.
rat LD50 intraperitoneal 147mg/kg (147mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3131, 1973.
rat LD50 intravenous 33mg/kg (33mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
rat LD50 oral 214mg/kg (214mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1236, 1985.
rat LD50 subcutaneous 940mg/kg (940mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
women LDLo oral 90mg/kg (90mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: GENERAL ANESTHETIC

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
British Medical Journal. Vol. 1, Pg. 552, 1977.
women TDLo oral 160mg/kg (160mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

VASCULAR: SHOCK
Human & Experimental Toxicology. Vol. 9, Pg. 101, 1990.