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Substance Name: Bepridil [INN:BAN]
RN: 64706-54-3
UNII: 755BO701MA
InChIKey: UIEATEWHFDRYRU-UHFFFAOYSA-N

Note

  • A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.

Molecular Formula

  • C24-H34-N2-O

Molecular Weight

  • 366.5456
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Bepridil
  • Bepridil [INN:BAN]

MeSH Heading

  • Bepridil

Synonyms

  • Bepridil
  • beta-((2-Methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine
  • CERM 1978
  • Org 5730
  • UNII-755BO701MA

Systematic Name

  • 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-

Registry Numbers

CAS Registry Number

  • 64706-54-3

FDA UNII

  • 755BO701MA

Related Registry Numbers

  • 68099-86-5 (mono-hydrochloride)
  • 74764-40-2 (mono-hydrochloride, mono-hydrate)

System Generated Number

  • 0064706543

Structure Descriptors

InChI

1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3

InChIKey

UIEATEWHFDRYRU-UHFFFAOYSA-N

Smiles

CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 90mg/kg/3W-I (90mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) American Heart Journal. Vol. 111, Pg. 1005, 1986.
women TDLo oral 180mg/kg/30D- (180mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) American Heart Journal. Vol. 111, Pg. 1005, 1986.