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Substance Name: Pyridoxine [INN:BAN]
RN: 65-23-6
UNII: KV2JZ1BI6Z
InChIKey: LXNHXLLTXMVWPM-UHFFFAOYSA-N

Note

  • The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

Molecular Formula

  • C8-H11-N-O3

Molecular Weight

  • 169.1789
 

Classification Codes

  • Antiviral (COVID-19)
  • Drug / Therapeutic Agent
  • Growth Substances
  • Human Data
  • Micronutrients
  • Vitamin B Complex
  • Vitamins

Names and Synonyms

Name of Substance

  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
  • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol
  • Pyridoxine
  • Pyridoxine [INN:BAN]

MeSH Heading

  • Pyridoxine

Synonyms

  • 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
  • 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
  • 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
  • 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]
  • 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
  • 2-Picoline-4,5-dimethanol, 3-hydroxy-
  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
  • 3-Hydroxy-4,5-dimethylol-alpha-picoline
  • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol
  • Adermine
  • EINECS 200-603-0
  • Gravidox
  • Hydoxin
  • NSC 759148
  • Piridossina
  • Piridossina [DCIT]
  • Piridoxina
  • Piridoxina [INN-Spanish]
  • Pyridoxin
  • Pyridoxine
  • Pyridoxinum
  • Pyridoxinum [INN-Latin]
  • Pyridoxol
  • Pyridoxolum
  • UNII-KV2JZ1BI6Z

Systematic Names

  • 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
  • Pyridoxine
  • Pyridoxol

Superlist Name

  • Pyridoxine

Registry Numbers

CAS Registry Number

  • 65-23-6

FDA UNII

  • KV2JZ1BI6Z

Other Registry Number

  • 2087491-32-3

Related Registry Number

  • 58-56-0 (hydrochloride)

System Generated Number

  • 0000065236

Structure Descriptors

InChI

InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3

InChIKey

LXNHXLLTXMVWPM-UHFFFAOYSA-N

Smiles

Cc1ncc(CO)c(CO)c1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 5143mg/kg/17W (5143mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC New England Journal of Medicine. Vol. 309, Pg. 445, 1983.
mouse LD50 intraperitoneal 966mg/kg (966mg/kg)   Farmakologiya i Toksikologiya Vol. 40, Pg. 371, 1977.
mouse LD50 intravenous 545mg/kg (545mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 683, 1960.
rat LD50 intraperitoneal 1500mg/kg (1500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Proceedings of the European Society for the Study of Drug Toxicity. Vol. 4, Pg. 179, 1964.
rat LD50 intravenous 657mg/kg (657mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 44, Pg. 147, 1940.
rat LD50 oral 4gm/kg (4000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.
rat LD50 subcutaneous 3100mg/kg (3100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.
women TDLo oral 139mg/kg/5Y-I (139mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS New England Journal of Medicine. Vol. 311, Pg. 986, 1984.
women TDLo oral 2100mg/kg/30D (2100mg/kg) BEHAVIORAL: ATAXIA

PERIPHERAL NERVE AND SENSATION: PARESTHESIS		 Neurology. Vol. 35, Pg. 1466, 1985.
women TDLo oral 4800mg/kg/17W (4800mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC New England Journal of Medicine. Vol. 309, Pg. 445, 1983.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 159-162 deg C   EXP
log P (octanol-water) -0.77 (none)   EXP
Water Solubility 2.82E+05 mg/L 25 EST
Vapor Pressure 2.84E-07 mm Hg 25 EST
Henry's Law Constant 1.32E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.06E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.