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Substance Name: Phentolamine mesilate [INN:BAN]
RN: 65-28-1
UNII: Y7543E5K9T
InChIKey: OGIYDFVHFQEFKQ-UHFFFAOYSA-N

Note

  • A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

Molecular Formula

  • C17-H19-N3-O.C-H4-O3-S

Molecular Weight

  • 377.4627
 

Classification Codes

  • Anti-Adrenergic
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Phentolamine mesilate [INN:BAN]

Name of Substance

  • Phentolamine mesylate [USP]

Synonyms

  • CCRIS 9022
  • EINECS 200-604-6
  • m-(N-(2-Imidazolin-2-ylmethyl)-p-toluidino)phenol monomethanesulfonate (salt)
  • OraVerse
  • Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)-, monomethanesulfonate (salt)
  • Phentolamine mesilate
  • Phentolamine mesilate [INN:BAN]
  • Phentolamine mesylate
  • Phentolamine methanesulfonate
  • Phentolamine methanesulphonate
  • Regitin methanesulphonate
  • Regitine
  • Regitine mesylate
  • Regitine methanesulfonate
  • UNII-Y7543E5K9T

Systematic Names

  • Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)-, monomethanesulfonate (salt)
  • Phenol, m-(N-(2-imidazolin-2-ylmethyl)-p-toluidino)-, monomethanesulfonate (salt)
  • Phentolamine mesilate

Registry Numbers

CAS Registry Number

  • 65-28-1

FDA UNII

  • Y7543E5K9T

Related Registry Number

  • 50-60-2 (Parent)

System Generated Number

  • 0000065281

Molecular Formulas

Molecular Formula

  • C17-H19-N3-O.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C17-H19-N3-O
  • COMPONENT

Structure Descriptors

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChIKey

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(c3)O.CS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 75mg/kg (75mg/kg)   Journal de Pharmacologie. Vol. 5, Pg. 101, 1974.
rabbit LDLo intravenous 35mg/kg (35mg/kg)   Drugs in Japan Vol. 6, Pg. 667, 1982.
rabbit LDLo subcutaneous 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 667, 1982.
rat LDLo intravenous 75mg/kg (75mg/kg)   Drugs in Japan Vol. 6, Pg. 667, 1982.
rat LDLo subcutaneous 275mg/kg (275mg/kg)   Drugs in Japan Vol. 6, Pg. 667, 1982.