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Substance Name: Nicotine tartrate
RN: 65-31-6
UNII: 7892ZN5G41
InChIKey: RFEJUZJILGIRHQ-OMDKHLBYSA-N

Note

  • Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Molecular Formula

  • C10-H14-N2.2C4-H6-O6

Molecular Weight

  • 462.4054
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Nicotine tartrate

Synonyms

  • EINECS 200-607-2
  • HSDB 806
  • Nicotine acid tartrate
  • Nicotine bitartrate
  • Nicotine ditartrate
  • Nicotine hydrogen tartarate
  • Nicotine hydrogen tartrate
  • Nicotine tartrate
  • Nicotine tartrate (VAN)
  • Nicotine tartrate dihydrate
  • Nicotine, tartrate (1:2)
  • Nicotine-D-bitartrate
  • Nikotinbitartrat
  • Nikotinbitartrat [German]
  • NSC 97238
  • Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2)
  • Tartrate de nicotine
  • Tartrate de nicotine [French]
  • UNII-7892ZN5G41

Systematic Names

  • Nicotine dihydrogen ditartrate
  • Nicotine, tartrate (1:2)
  • Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2)
  • Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2) (9CI)

Superlist Names

  • Nicotine tartrate [UN1659] [Poison]
  • UN1659

Registry Numbers

CAS Registry Number

  • 65-31-6

FDA UNII

  • 7892ZN5G41

System Generated Number

  • 0000065316

Molecular Formulas

Molecular Formula

  • C10-H14-N2.2C4-H6-O6

Molecular Formula Fragments

  • C10-H14-N2
  • C4-H6-O6
  • COMPONENT

Structure Descriptors

InChI

1S/C10H14N2.2C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t10-;2*1-,2-/m011/s1

InChIKey

RFEJUZJILGIRHQ-OMDKHLBYSA-N

Smiles

CN1CCC[C@H]1c2cccnc2.O[C@H]([C@@H](O)C(=O)O)C(=O)O.O[C@H]([C@@H](O)C(=O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LD50 parenteral 337mg/kg (337mg/kg)   Acta Biologica et Medica Germanica. Vol. 28, Pg. 681, 1972.
hamster LD50 intraperitoneal 125mg/kg (125mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 324, 1972.
mouse LD50 intraperitoneal 9100ug/kg (9.1mg/kg)   Toxicology and Applied Pharmacology. Vol. 65, Pg. 366, 1982.
mouse LD50 intravenous 300ug/kg (0.3mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Pharmacology. Vol. 35, Pg. 161, 1969.
mouse LD50 oral 65mg/kg (65mg/kg)   Pharmacological Research Communications. Vol. 5, Pg. 341, 1973.
mouse LD50 subcutaneous 53mg/kg (53mg/kg)   Pharmacological Research Communications. Vol. 5, Pg. 341, 1973.
rat LD50 intraperitoneal 83mg/kg (83mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 324, 1972.
rat LD50 intravenous 600mg/kg (600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Pharmacological Research Communications. Vol. 5, Pg. 341, 1973.
rat LD50 oral 65mg/kg (65mg/kg)   Pharmacological Research Communications. Vol. 5, Pg. 341, 1973.
rat LD50 parenteral 33500ug/kg (33.5mg/kg)   Acta Biologica et Medica Germanica. Vol. 28, Pg. 681, 1972.
rat LD50 unreported 30mg/kg (30mg/kg)   Schweizerische Medizinische Wochenschrift. Vol. 91, Pg. 359, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -6.540 (none)   EST
Water Solubility 1.00E+06 mg/L 25 EST
Vapor Pressure 9.26E-22 mm Hg 25 EST
Atmospheric OH Rate Constant 1.11E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.