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Substance Name: Salicylamide [USP:INN:BAN:JAN]
RN: 65-45-2
UNII: EM8BM710ZC
InChIKey: SKZKKFZAGNVIMN-UHFFFAOYSA-N

Molecular Formula

  • C7-H7-N-O2

Molecular Weight

  • 137.1373
 

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • 2-Hydroxybenzamide
  • Benzamide, 2-hydroxy-
  • Salicylamide
  • Salicylamide [USP:INN:BAN:JAN]

Synonyms

  • 2-Carbamoylphenol
  • 2-Carboxamidophenol
  • 2-Hydroxybenzamide
  • 4-10-00-00169 (Beilstein Handbook Reference)
  • Acket
  • Afko-Sal
  • AI3-03454
  • Algamon
  • Algiamida
  • Allevin
  • Amid kyseliny salicylove
  • Amid kyseliny salicylove [Czech]
  • Amid-Sal
  • Amidosal
  • Anamid
  • Andasol
  • Benesal
  • Benesal (VAN)
  • Benzamide, 2-hydroxy-
  • Benzamide, o-hydroxy-
  • Benzoic acid, 2-hydroxy-, amide
  • BRN 0742439
  • CCRIS 6045
  • Cetamide
  • Cymidon
  • Cymidon (VAN)
  • Dolomide
  • Dropsprin
  • EC 200-609-3
  • Eggosalil
  • EINECS 200-609-3
  • Flarpirina
  • H.P. 34
  • HSDB 227
  • Liquiprin
  • Morsarinas
  • Novecyl
  • NSC 3115
  • o-Hydroxybenzamide
  • OHB
  • Oramid
  • Panithal
  • Raspberin
  • Salamid
  • Salamide
  • Saliamid
  • Saliamin
  • Salicilamida
  • Salicilamida [INN-Spanish]
  • Salicilamide
  • Salicilamide [DCIT]
  • Salicilamide [Italian]
  • Salicim
  • Salicylamide
  • Salicylamidum
  • Salicylamidum [INN-Latin]
  • Salicylic acid amide
  • Salipur
  • Salizell
  • Salizell (VAN)
  • Salrin
  • Salymid
  • Serramida
  • SR 4326
  • UNII-EM8BM710ZC
  • Urtosal

Systematic Names

  • 2-Hydroxybenzamide
  • Benzamide, 2-hydroxy-
  • Salicylamide

Mixture Name

  • Rhinex D-Lay Tablets

Registry Numbers

CAS Registry Number

  • 65-45-2

FDA UNII

  • EM8BM710ZC

Related Registry Number

  • 36205-82-0 (mono-hydrochloride salt)

System Generated Number

  • 0000065452

Structure Descriptors

InChI

1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)

InChIKey

SKZKKFZAGNVIMN-UHFFFAOYSA-N

Smiles

c1(c(cccc1)O)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
cat LDLo oral 150mg/kg (150mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
dog LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
guinea pig LD50 oral 1730mg/kg (1730mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
guinea pig LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
mouse LD50 intraperitoneal 180mg/kg (180mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
mouse LD50 intravenous 313mg/kg (313mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
mouse LD50 oral 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
mouse LD50 subcutaneous 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.
rabbit LD50 oral 3200mg/kg (3200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
rabbit LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
rat LD50 intraperitoneal 600mg/kg (600mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 450, 1953.
rat LD50 oral 980mg/kg (980mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 142 deg C   EXP
Boiling Point 181.5 deg C   EXP
pKa Dissociation Constant 8.37 (none) 20 EXP
log P (octanol-water) 1.28 (none)   EXP
Water Solubility 2060 mg/L 25 EXP
Vapor Pressure 6.90E-06 mm Hg 25 EST
Henry's Law Constant 2.90E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.25E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.