|
|
Substance Name: Salicylamide [USP:INN:BAN:JAN]
RN: 65-45-2
UNII: EM8BM710ZC
InChIKey: SKZKKFZAGNVIMN-UHFFFAOYSA-N
Molecular Formula
- C7-H7-N-O2
Molecular Weight
- 137.1373
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
- Skin / Eye Irritant
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- 2-Hydroxybenzamide
- Benzamide, 2-hydroxy-
- Salicylamide
- Salicylamide [USP:INN:BAN:JAN]
Synonyms
- 2-Carbamoylphenol
- 2-Carboxamidophenol
- 2-Hydroxybenzamide
- 4-10-00-00169 (Beilstein Handbook Reference)
- Acket
- Afko-Sal
- AI3-03454
- Algamon
- Algiamida
- Allevin
- Amid kyseliny salicylove
- Amid kyseliny salicylove [Czech]
- Amid-Sal
- Amidosal
- Anamid
- Andasol
- Benesal
- Benesal (VAN)
- Benzamide, 2-hydroxy-
- Benzamide, o-hydroxy-
- Benzoic acid, 2-hydroxy-, amide
- BRN 0742439
- CCRIS 6045
- Cetamide
- Cymidon
- Cymidon (VAN)
- Dolomide
- Dropsprin
- EC 200-609-3
- Eggosalil
- EINECS 200-609-3
- Flarpirina
- H.P. 34
- HSDB 227
- Liquiprin
- Morsarinas
- Novecyl
- NSC 3115
- o-Hydroxybenzamide
- OHB
- Oramid
- Panithal
- Raspberin
- Salamid
- Salamide
- Saliamid
- Saliamin
- Salicilamida
- Salicilamida [INN-Spanish]
- Salicilamide
- Salicilamide [DCIT]
- Salicilamide [Italian]
- Salicim
- Salicylamide
- Salicylamidum
- Salicylamidum [INN-Latin]
- Salicylic acid amide
- Salipur
- Salizell
- Salizell (VAN)
- Salrin
- Salymid
- Serramida
- SR 4326
- UNII-EM8BM710ZC
- Urtosal
Systematic Names
- 2-Hydroxybenzamide
- Benzamide, 2-hydroxy-
- Salicylamide
Mixture Name
- Rhinex D-Lay Tablets
Registry Numbers
CAS Registry Number
- 65-45-2
FDA UNII
- EM8BM710ZC
Related Registry Number
- 36205-82-0 (mono-hydrochloride salt)
System Generated Number
- 0000065452
Structure Descriptors
InChI
InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)InChIKey
SKZKKFZAGNVIMN-UHFFFAOYSA-NSmiles
NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
cat | LDLo | oral | 150mg/kg (150mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
dog | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
guinea pig | LD50 | oral | 1730mg/kg (1730mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
guinea pig | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
mouse | LD50 | intraperitoneal | 180mg/kg (180mg/kg) | Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972. | |
mouse | LD50 | intravenous | 313mg/kg (313mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
mouse | LD50 | oral | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
mouse | LD50 | subcutaneous | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. | |
rabbit | LD50 | oral | 3200mg/kg (3200mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
rabbit | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
rat | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 450, 1953. | |
rat | LD50 | oral | 980mg/kg (980mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 142 | deg C | EXP | |
Boiling Point | 181.5 | deg C | EXP | |
pKa Dissociation Constant | 8.37 | (none) | 20 | EXP |
log P (octanol-water) | 1.28 | (none) | EXP | |
Water Solubility | 2060 | mg/L | 25 | EXP |
Vapor Pressure | 6.90E-06 | mm Hg | 25 | EST |
Henry's Law Constant | 2.90E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.25E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.