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Substance Name: Salicylamide [USP:INN:BAN:JAN]
RN: 65-45-2
UNII: EM8BM710ZC
InChIKey: SKZKKFZAGNVIMN-UHFFFAOYSA-N
Molecular Formula
- C7-H7-N-O2
Molecular Weight
- 137.1373
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
- Skin / Eye Irritant
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Links to Resources
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Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- 2-Hydroxybenzamide
- Benzamide, 2-hydroxy-
- Salicylamide
- Salicylamide [USP:INN:BAN:JAN]
Synonyms
- 2-Carbamoylphenol
- 2-Carboxamidophenol
- 2-Hydroxybenzamide
- 4-10-00-00169 (Beilstein Handbook Reference)
- Acket
- Afko-Sal
- AI3-03454
- Algamon
- Algiamida
- Allevin
- Amid kyseliny salicylove
- Amid kyseliny salicylove [Czech]
- Amid-Sal
- Amidosal
- Anamid
- Andasol
- Benesal
- Benesal (VAN)
- Benzamide, 2-hydroxy-
- Benzamide, o-hydroxy-
- Benzoic acid, 2-hydroxy-, amide
- BRN 0742439
- CCRIS 6045
- Cetamide
- Cymidon
- Cymidon (VAN)
- Dolomide
- Dropsprin
- EC 200-609-3
- Eggosalil
- EINECS 200-609-3
- Flarpirina
- H.P. 34
- HSDB 227
- Liquiprin
- Morsarinas
- Novecyl
- NSC 3115
- o-Hydroxybenzamide
- OHB
- Oramid
- Panithal
- Raspberin
- Salamid
- Salamide
- Saliamid
- Saliamin
- Salicilamida
- Salicilamida [INN-Spanish]
- Salicilamide
- Salicilamide [DCIT]
- Salicilamide [Italian]
- Salicim
- Salicylamide
- Salicylamidum
- Salicylamidum [INN-Latin]
- Salicylic acid amide
- Salipur
- Salizell
- Salizell (VAN)
- Salrin
- Salymid
- Serramida
- SR 4326
- UNII-EM8BM710ZC
- Urtosal
Systematic Names
- 2-Hydroxybenzamide
- Benzamide, 2-hydroxy-
- Salicylamide
Mixture Name
- Rhinex D-Lay Tablets
Registry Numbers
CAS Registry Number
- 65-45-2
FDA UNII
- EM8BM710ZC
Related Registry Number
- 36205-82-0 (mono-hydrochloride salt)
System Generated Number
- 0000065452
Structure Descriptors
InChI
InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)InChIKey
SKZKKFZAGNVIMN-UHFFFAOYSA-NSmiles
NC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| cat | LDLo | oral | 150mg/kg (150mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
| dog | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| guinea pig | LD50 | oral | 1730mg/kg (1730mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
| guinea pig | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| mouse | LD50 | intraperitoneal | 180mg/kg (180mg/kg) | Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972. | |
| mouse | LD50 | intravenous | 313mg/kg (313mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| mouse | LD50 | oral | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
| mouse | LD50 | subcutaneous | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. | |
| rabbit | LD50 | oral | 3200mg/kg (3200mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
| rabbit | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| rat | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 450, 1953. | |
| rat | LD50 | oral | 980mg/kg (980mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 142 | deg C | EXP | |
| Boiling Point | 181.5 | deg C | EXP | |
| pKa Dissociation Constant | 8.37 | (none) | 20 | EXP |
| log P (octanol-water) | 1.28 | (none) | EXP | |
| Water Solubility | 2060 | mg/L | 25 | EXP |
| Vapor Pressure | 6.90E-06 | mm Hg | 25 | EST |
| Henry's Law Constant | 2.90E-10 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 3.25E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.