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Substance Name: Aminosalicylic Acid [USP]
RN: 65-49-6
UNII: 5B2658E0N2
InChIKey: WUBBRNOQWQTFEX-UHFFFAOYSA-N

Note

  • An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.

Molecular Formula

  • C7-H7-N-O3

Molecular Weight

  • 153.1363
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial (Tuberculostatic)
  • Antitubercular Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Skin / Eye Irritant

Names and Synonyms

Name of Substance

  • Aminosalicylic Acid [USP]
  • p-Aminosalicylic acid

MeSH Heading

  • Aminosalicylic acid

Synonyms

  • 2-Hydroxy-4-aminobenzoic acid
  • 3-Hydroxy-4-carboxyaniline
  • 4-14-00-01967 (Beilstein Handbook Reference)
  • 4-Amino-2-hydroxybenzoic acid
  • 4-Aminosalicylic acid
  • A 1909
  • AI3-50142
  • Aminopar
  • Aminosalicylic acid
  • Aminosalyl
  • Aminox
  • Apacil
  • APAS
  • Benzoic acid, 4-amino-2-hydroxy-
  • BRN 0473071
  • Deapasil
  • EINECS 200-613-5
  • Entepas
  • Ferrosan
  • Gabbropas
  • Helipidyl
  • Hellipidyl
  • HSDB 3203
  • Kyselina p-aminosalicylova
  • Kyselina p-aminosalicylova [Czech]
  • NIH 2939
  • NSC 2083
  • Osacyl
  • p-Aminosalicylic acid
  • P.A.S
  • Pamacyl
  • Pamisyl
  • Para-amino salicylic acid
  • Para-Pas
  • Paramycin
  • Parasal
  • Parasalicil
  • Parasalindon
  • PAS
  • PAS (acid)
  • PAS (VAN)
  • PAS-C
  • Pasa
  • Pasalon
  • Pasara
  • Pascorbic
  • Pasdium
  • Pasem
  • Paser
  • Paser Granules
  • Pask
  • Pasmed
  • Pasnodia
  • Pasolac
  • Propasa
  • Rezipas
  • Salicylic acid, 4-amino-
  • Sanipirol-4
  • UNII-5B2658E0N2

Systematic Names

  • 4-Aminosalicylic acid
  • Benzoic acid, 4-amino-2-hydroxy-
  • Salicylic acid, 4-amino-

Superlist Name

  • 4-Aminosalicylic acid

Registry Numbers

CAS Registry Number

  • 65-49-6

FDA UNII

  • 5B2658E0N2

Related Registry Numbers

  • 133-09-5 (mono-potassium salt)
  • 133-10-8 (mono-hydrochloride salt)
  • 133-15-3 (calcium (2:1) salt)
  • 6018-19-5 (mono-hydrochloride salt, di-hydrate)

System Generated Number

  • 0000065496

Structure Descriptors

InChI

1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

InChIKey

WUBBRNOQWQTFEX-UHFFFAOYSA-N

Smiles

c1cc(c(cc1N)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4250mg/kg (4250mg/kg)   Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
mouse LD50 intravenous 3898mg/kg (3898mg/kg)   Antibiotiki. Vol. 18, Pg. 249, 1973.
mouse LD50 oral 4gm/kg (4000mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950.
mouse LD50 subcutaneous 4gm/kg (4000mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950.
rabbit LD50 oral 3650mg/kg (3650mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 10, Pg. 289, 1951.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 150.5 dec deg C   EXP
pKa Dissociation Constant 2.05 (none) 25 EXP
log P (octanol-water) 0.89 (none)   EXP
Water Solubility 1690 mg/L 23 EXP
Vapor Pressure 4.00E-06 mm Hg 25 EST
Henry's Law Constant 5.02E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.01E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.