|
|
Substance Name: Aminosalicylic Acid [USP]
RN: 65-49-6
UNII: 5B2658E0N2
InChIKey: WUBBRNOQWQTFEX-UHFFFAOYSA-N
Note
- An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
Molecular Formula
- C7-H7-N-O3
Molecular Weight
- 153.1363
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial (Tuberculostatic)
- Antitubercular Agents
- Drug / Therapeutic Agent
- Mutation Data
- Skin / Eye Irritant
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Aminosalicylic Acid [USP]
- p-Aminosalicylic acid
MeSH Heading
- Aminosalicylic acid
Synonyms
- 2-Hydroxy-4-aminobenzoic acid
- 3-Hydroxy-4-carboxyaniline
- 4-14-00-01967 (Beilstein Handbook Reference)
- 4-Amino-2-hydroxybenzoic acid
- 4-Aminosalicylic acid
- A 1909
- AI3-50142
- Aminopar
- Aminosalicylic acid
- Aminosalyl
- Aminox
- Apacil
- APAS
- Benzoic acid, 4-amino-2-hydroxy-
- BRN 0473071
- Deapasil
- EINECS 200-613-5
- Entepas
- Ferrosan
- Gabbropas
- Granupas
- Helipidyl
- Hellipidyl
- HSDB 3203
- Kyselina p-aminosalicylova
- Kyselina p-aminosalicylova [Czech]
- NIH 2939
- NSC 2083
- Osacyl
- p-Aminosalicylic acid
- P.A.S
- Pamacyl
- Pamisyl
- Para-amino salicylic acid
- Para-Aminosalicylic acid
- Para-Pas
- Paramycin
- Parasal
- Parasalicil
- Parasalindon
- PAS
- PAS (acid)
- PAS (VAN)
- PAS-C
- Pasa
- Pasalon
- Pasara
- Pascorbic
- Pasdium
- Pasem
- Paser
- Paser Granules
- Pask
- Pasmed
- Pasnodia
- Pasolac
- Propasa
- Rezipas
- Salicylic acid, 4-amino-
- Sanipirol-4
- UNII-5B2658E0N2
Systematic Names
- 4-Aminosalicylic acid
- Benzoic acid, 4-amino-2-hydroxy-
- Salicylic acid, 4-amino-
Superlist Name
- 4-Aminosalicylic acid
Registry Numbers
CAS Registry Number
- 65-49-6
FDA UNII
- 5B2658E0N2
Other Registry Number
- 2220148-96-7
Related Registry Numbers
- 133-09-5 (mono-potassium salt)
- 133-10-8 (mono-hydrochloride salt)
- 133-15-3 (calcium (2:1) salt)
- 6018-19-5 (mono-hydrochloride salt, di-hydrate)
System Generated Number
- 0000065496
Structure Descriptors
InChI
InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)InChIKey
WUBBRNOQWQTFEX-UHFFFAOYSA-NSmiles
Nc1ccc(C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 4250mg/kg (4250mg/kg) | Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. | |
mouse | LD50 | intravenous | 3898mg/kg (3898mg/kg) | Antibiotiki. Vol. 18, Pg. 249, 1973. | |
mouse | LD50 | oral | 4gm/kg (4000mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950. | |
mouse | LD50 | subcutaneous | 4gm/kg (4000mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950. | |
rabbit | LD50 | oral | 3650mg/kg (3650mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 10, Pg. 289, 1951. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 150.5 dec | deg C | EXP | |
pKa Dissociation Constant | 2.05 | (none) | 25 | EXP |
log P (octanol-water) | 0.89 | (none) | EXP | |
Water Solubility | 1690 | mg/L | 23 | EXP |
Vapor Pressure | 4.00E-06 | mm Hg | 25 | EST |
Henry's Law Constant | 5.02E-12 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.01E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.