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Substance Name: Aminosalicylic Acid [USP]
RN: 65-49-6
UNII: 5B2658E0N2
InChIKey: WUBBRNOQWQTFEX-UHFFFAOYSA-N
Note
- An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
Molecular Formula
- C7-H7-N-O3
Molecular Weight
- 153.1363
- All
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial (Tuberculostatic)
- Antitubercular Agents
- Drug / Therapeutic Agent
- Mutation Data
- Skin / Eye Irritant
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Names and Synonyms
Name of Substance
- Aminosalicylic Acid [USP]
- p-Aminosalicylic acid
MeSH Heading
- Aminosalicylic acid
Synonyms
- 2-Hydroxy-4-aminobenzoic acid
- 3-Hydroxy-4-carboxyaniline
- 4-14-00-01967 (Beilstein Handbook Reference)
- 4-Amino-2-hydroxybenzoic acid
- 4-Aminosalicylic acid
- A 1909
- AI3-50142
- Aminopar
- Aminosalicylic acid
- Aminosalyl
- Aminox
- Apacil
- APAS
- Benzoic acid, 4-amino-2-hydroxy-
- BRN 0473071
- Deapasil
- EINECS 200-613-5
- Entepas
- Ferrosan
- Gabbropas
- Helipidyl
- Hellipidyl
- HSDB 3203
- Kyselina p-aminosalicylova
- Kyselina p-aminosalicylova [Czech]
- NIH 2939
- NSC 2083
- Osacyl
- p-Aminosalicylic acid
- P.A.S
- Pamacyl
- Pamisyl
- Para-amino salicylic acid
- Para-Pas
- Paramycin
- Parasal
- Parasalicil
- Parasalindon
- PAS
- PAS (acid)
- PAS (VAN)
- PAS-C
- Pasa
- Pasalon
- Pasara
- Pascorbic
- Pasdium
- Pasem
- Paser
- Paser Granules
- Pask
- Pasmed
- Pasnodia
- Pasolac
- Propasa
- Rezipas
- Salicylic acid, 4-amino-
- Sanipirol-4
- UNII-5B2658E0N2
Systematic Names
- 4-Aminosalicylic acid
- Benzoic acid, 4-amino-2-hydroxy-
- Salicylic acid, 4-amino-
Superlist Name
- 4-Aminosalicylic acid
Registry Numbers
CAS Registry Number
- 65-49-6
FDA UNII
- 5B2658E0N2
Related Registry Numbers
- 133-09-5 (mono-potassium salt)
- 133-10-8 (mono-hydrochloride salt)
- 133-15-3 (calcium (2:1) salt)
- 6018-19-5 (mono-hydrochloride salt, di-hydrate)
System Generated Number
- 0000065496
Structure Descriptors
InChI
1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)InChIKey
WUBBRNOQWQTFEX-UHFFFAOYSA-NSmiles
c1cc(c(cc1N)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 4250mg/kg (4250mg/kg) | Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. | |
| mouse | LD50 | intravenous | 3898mg/kg (3898mg/kg) | Antibiotiki. Vol. 18, Pg. 249, 1973. | |
| mouse | LD50 | oral | 4gm/kg (4000mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950. | |
| mouse | LD50 | subcutaneous | 4gm/kg (4000mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950. | |
| rabbit | LD50 | oral | 3650mg/kg (3650mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 10, Pg. 289, 1951. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 150.5 dec | deg C | EXP | |
| pKa Dissociation Constant | 2.05 | (none) | 25 | EXP |
| log P (octanol-water) | 0.89 | (none) | EXP | |
| Water Solubility | 1690 | mg/L | 23 | EXP |
| Vapor Pressure | 4.00E-06 | mm Hg | 25 | EST |
| Henry's Law Constant | 5.02E-12 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.01E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.