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Substance Name: Indeloxazine hydrochloride [USAN:JAN]
RN: 65043-22-3
UNII: 15QZ6NE84E
InChIKey: KEBHLNDPKPIPLI-UHFFFAOYSA-N

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C14-H17-N-O2.Cl-H

Molecular Weight

  • 267.754
 
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Names and Synonyms

Name of Substance

  • Indeloxazine hydrochloride
  • Indeloxazine hydrochloride [USAN:JAN]

Synonyms

  • (+-)-2-((Inden-7-yloxy)methyl)morpholine hydrochloride
  • 2-((1H-Inden-7-yloxy)methyl)morpholine hydrochloride
  • CI 874
  • CI-874
  • Indeloxazine HCl
  • Indeloxazine hydrochloride
  • Morpholine, 2-((1H-inden-7-yloxy)methyl)-, hydrochloride, (+-)-
  • UNII-15QZ6NE84E
  • YM 08054-1
  • YM-08054-1

Systematic Name

  • Morpholine, 2-((1H-inden-7-yloxy)methyl)-, hydrochloride, (+-)-

Registry Numbers

CAS Registry Number

  • 65043-22-3

FDA UNII

  • 15QZ6NE84E

Related Registry Number

  • 60929-23-9 (Parent)

System Generated Number

  • 0065043223

Molecular Formulas

Molecular Formula

  • C14-H17-N-O2.Cl-H

Molecular Formula Fragments

  • C14-H17-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H17NO2.ClH/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12;/h1-4,6,12,15H,5,7-10H2;1H

InChIKey

KEBHLNDPKPIPLI-UHFFFAOYSA-N

Smiles

c12c(OC[C@@H]3CNCCO3)cccc1C=CC2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 60mg/kg (60mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse LD50 intraperitoneal 50400ug/kg (50.4mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 1181, 1988.
mouse LD50 intravenous 47mg/kg (47mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 238, Pg. 81, 1979.
mouse LD50 oral 340mg/kg (340mg/kg)   United States Patent Document. Vol. #4297356,
mouse LD50 subcutaneous 245mg/kg (245mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat LD50 intravenous 77300ug/kg (77.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat LD50 oral 502mg/kg (502mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat LD50 subcutaneous 206mg/kg (206mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.