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Substance Name: Veratrum alkaloids
RN: 65072-04-0
UNII: 4I27BB349X

Notes

  • A plant genus of the family RANUNCULACEAE. Members contain hellebrin (BUFANOLIDES). The extract is the basis of Biocil preparation used for rheumatism.
  • Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Natural Product
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Links to Resources

Names and Synonyms

Name of Substance

  • Veratrum alkaloids
  • Veratrum viride

MeSH Heading

  • Veratrum Alkaloids

Synonyms

  • Alkaloids, veratrum
  • Alkavervir
  • American hellebore
  • American veratrum
  • Green hellebore
  • HSDB 1951
  • Indian poke
  • UNII-4I27BB349X
  • Veratrum alkaloids
  • Veratrum viride
  • Veratrum viride alkaloids extract
  • Veratrum viride root
  • Veriloid
  • Vertavis

Systematic Name

  • Veriloid

Registry Numbers

CAS Registry Number

  • 65072-04-0

FDA UNII

  • 4I27BB349X

Other Registry Number

  • 8002-39-9

System Generated Number

  • 0065072040

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 500ug/kg (0.5mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 725, 1949.
dog LDLo oral 3mg/kg (3mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 intraperitoneal 3mg/kg (3mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951.
mouse LD50 intravenous 430ug/kg (0.43mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 400, 1954.
mouse LD50 oral 4500ug/kg (4.5mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951.
mouse LD50 subcutaneous 1120ug/kg (1.12mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 610, 1950.
rabbit LD50 intravenous 270ug/kg (0.27mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951.
rabbit LD50 oral 18mg/kg (18mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951.
rat LD50 intraperitoneal 1690ug/kg (1.69mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951.
rat LD50 intravenous 440ug/kg (0.44mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951.
rat LD50 oral 12mg/kg (12mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 257, 1950.
rat LD50 subcutaneous 1590ug/kg (1.59mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 610, 1950.