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Substance Name: Nitracrine dihydrochloride
RN: 6514-85-8
UNII: T450D0Q71D
InChIKey: XBHIADYHFGJGSK-UHFFFAOYSA-N

Note

  • Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C18-H20-N4-O2.2Cl-H

Molecular Weight

  • 397.3038
 
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Names and Synonyms

Results Name

  • Nitracrine dihydrochloride

Name of Substance

  • Nitracrine dihydrochloride

Synonyms

  • 1-Nitro-9-(3-dimethylaminopropylamino)-acridine dihydrochloride
  • C 283
  • C-283
  • CCRIS 9297
  • Ledacrine
  • Ledakrin
  • Nitracrine dihydrochloride
  • Nitracrine HCl
  • NSC 247561
  • UNII-T450D0Q71D

Systematic Names

  • 1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, dihydrochloride (9CI)
  • Acridine, 9-((3-(dimethylamino)propyl)amino)-1-nitro-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 6514-85-8

FDA UNII

  • T450D0Q71D

System Generated Number

  • 0006514858

Molecular Formulas

Molecular Formula

  • C18-H20-N4-O2.2Cl-H

Molecular Formula Fragments

  • C18-H20-N4-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H20N4O2.2ClH/c1-21(2)12-6-11-19-18-13-7-3-4-8-14(13)20-15-9-5-10-16(17(15)18)22(23)24;;/h3-5,7-10H,6,11-12H2,1-2H3,(H,19,20);2*1H

InChIKey

XBHIADYHFGJGSK-UHFFFAOYSA-N

Smiles

C[NH+](C)CCC[NH2+]c1c2ccccc2nc3c1c(ccc3)[N+](=O)[O-].[Cl-].[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1010ug/kg (1.01mg/kg) GASTROINTESTINAL: OTHER CHANGES Archivum Immunologiae et Therapiae Experimentalis. Vol. 20, Pg. 399, 1972.
mouse LD50 oral 34050ug/kg (34.05mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Archivum Immunologiae et Therapiae Experimentalis. Vol. 20, Pg. 399, 1972.
mouse LD50 subcutaneous 1mg/kg (1mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 31, Pg. 661, 1979.
pigeon LD50 intravenous 1010ug/kg (1.01mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Archivum Immunologiae et Therapiae Experimentalis. Vol. 28, Pg. 777, 1980.
rat LD50 intravenous 725ug/kg (0.725mg/kg) GASTROINTESTINAL: OTHER CHANGES Archivum Immunologiae et Therapiae Experimentalis. Vol. 20, Pg. 399, 1972.
rat LD50 oral 25750ug/kg (25.75mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Archivum Immunologiae et Therapiae Experimentalis. Vol. 20, Pg. 399, 1972.