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Substance Name: Mitoxantrone [INN:BAN]
RN: 65271-80-9
UNII: BZ114NVM5P
InChIKey: KKZJGLLVHKMTCM-UHFFFAOYSA-N
Note
- An anthracenedione-derived antineoplastic agent.
Molecular Formula
- C22-H28-N4-O6
Molecular Weight
- 444.485
Classification Codes
- Analgesics
- Antineoplastic Agents
- Central Nervous System Agents
- DNA Topoisomerase II Inhibitor
- Enzyme Inhibitors
- Mutation Data
- Peripheral Nervous System Agents
- Sensory System Agents
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
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Names and Synonyms
Name of Substance
- Mitoxantrone
- Mitoxantrone [INN:BAN]
MeSH Heading
- Mitoxantrone
Synonyms
- 1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone
- 1,4-Dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione
- 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon
- 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone
- BRN 2795126
- CCRIS 7604
- DHAQ
- Dihydroxyanthraquinone
- Mitoxanthrone
- Mitoxantrona
- Mitoxantrona [INN-Spanish]
- Mitoxantrone
- Mitoxantronum
- Mitoxantronum [INN-Latin]
- Mitozantrone
- Novantron
- NSC 279836
- UNII-BZ114NVM5P
Systematic Names
- 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)- (9CI)
- Anthraquinone, 5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxy-
- Mitoxantron
Superlist Name
- Mitoxantrone
Registry Numbers
CAS Registry Number
- 65271-80-9
FDA UNII
- BZ114NVM5P
Other Registry Numbers
- 137635-96-2
- 70945-62-9
Related Registry Numbers
- 70476-82-3 (hydrochloride)
- 70711-41-0 (acetate)
System Generated Number
- 0065271809
Structure Descriptors
InChI
InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2InChIKey
KKZJGLLVHKMTCM-UHFFFAOYSA-NSmiles
OCCNCCNc1ccc(NCCNCCO)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 7100ug/kg (7.1mg/kg) | Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. Vol. 20, Pg. 303, 1989. | |
mouse | LD50 | intravenous | 6600ug/kg (6.6mg/kg) | Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. Vol. 20, Pg. 303, 1989. | |
mouse | LD50 | subcutaneous | 20910ug/kg (20.91mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
mouse | LD50 | unreported | 86500ug/kg (86.5mg/kg) | Cancer Research. Vol. 46, Pg. 2703, 1986. | |
rabbit | LD50 | intrapleural | 2mg/kg (2mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) | Lung. Vol. 174, Pg. 373, 1996. |