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Substance Name: Mitoxantrone [INN:BAN]
RN: 65271-80-9
UNII: BZ114NVM5P
InChIKey: KKZJGLLVHKMTCM-UHFFFAOYSA-N

Note

  • An anthracenedione-derived antineoplastic agent.

Molecular Formula

  • C22-H28-N4-O6

Molecular Weight

  • 444.485
 

Classification Codes

  • Analgesics
  • Antineoplastic Agents
  • Central Nervous System Agents
  • DNA Topoisomerase II Inhibitor
  • Enzyme Inhibitors
  • Mutation Data
  • Peripheral Nervous System Agents
  • Sensory System Agents
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors

Names and Synonyms

Name of Substance

  • Mitoxantrone
  • Mitoxantrone [INN:BAN]

MeSH Heading

  • Mitoxantrone

Synonyms

  • 1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone
  • 1,4-Dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione
  • 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon
  • 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone
  • BRN 2795126
  • CCRIS 7604
  • DHAQ
  • Dihydroxyanthraquinone
  • Mitoxanthrone
  • Mitoxantrona
  • Mitoxantrona [INN-Spanish]
  • Mitoxantrone
  • Mitoxantronum
  • Mitoxantronum [INN-Latin]
  • Mitozantrone
  • Novantron
  • NSC 279836
  • UNII-BZ114NVM5P

Systematic Names

  • 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)- (9CI)
  • Anthraquinone, 5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxy-
  • Mitoxantron

Superlist Name

  • Mitoxantrone

Registry Numbers

CAS Registry Number

  • 65271-80-9

FDA UNII

  • BZ114NVM5P

Other Registry Numbers

  • 137635-96-2
  • 70945-62-9

Related Registry Numbers

  • 70476-82-3 (hydrochloride)
  • 70711-41-0 (acetate)

System Generated Number

  • 0065271809

Structure Descriptors

InChI

1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2

InChIKey

KKZJGLLVHKMTCM-UHFFFAOYSA-N

Smiles

c12c(c(ccc1NCCNCCO)NCCNCCO)C(c1c(ccc(c1C2=O)O)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 7100ug/kg (7.1mg/kg)   Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. Vol. 20, Pg. 303, 1989.
mouse LD50 intravenous 6600ug/kg (6.6mg/kg)   Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. Vol. 20, Pg. 303, 1989.
mouse LD50 subcutaneous 20910ug/kg (20.91mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 unreported 86500ug/kg (86.5mg/kg)   Cancer Research. Vol. 46, Pg. 2703, 1986.
rabbit LD50 intrapleural 2mg/kg (2mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)
Lung. Vol. 174, Pg. 373, 1996.