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Substance Name: Sitagliptin phosphate [USAN]
RN: 654671-77-9
UNII: TS63EW8X6F
InChIKey: GQPYTJVDPQTBQC-KLQYNRQASA-N

Note

  • A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.

Molecular Formula

  • C16-H15-F6-N5-O.H3-O4-P.H2-O

Molecular Weight

  • 523.325
 

Classification Codes

  • Dipeptidyl-Peptidase IV Inhibitors
  • Enzyme Inhibitors
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Hypoglycemic Agents
  • Incretins
  • Protease Inhibitors
  • Treatment of Type 2 Diabetes Mellitus and Related Disorders

Names and Synonyms

Name of Substance

  • Sitagliptin phosphate [USAN]

MeSH Heading

  • Sitagliptin Phosphate

Synonyms

  • 7-((3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4- triazolo(4,3-a)pyrazine monophosphate monohydrate
  • Januvia
  • Sitagliptin phosphate
  • Sitagliptin phosphate hydrate
  • Sitagliptin phosphate monohydrate
  • UNII-TS63EW8X6F

Systematic Name

  • 1,2,4-Triazolo(4,3-a)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8- tetrahydro-3-(trifluoromethyl)-, phosphate (1:1) monohydrate

Registry Numbers

CAS Registry Number

  • 654671-77-9

FDA UNII

  • TS63EW8X6F

System Generated Number

  • 0654671779

Structure Descriptors

InChI

1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1

InChIKey

GQPYTJVDPQTBQC-KLQYNRQASA-N

Smiles

O.N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc3cc(F)c(F)cc3F.OP(=O)(O)O