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Substance Name: Thozalinone [USAN]
RN: 655-05-0
UNII: 68X5932947
InChIKey: JJSHYECKYLDYAR-UHFFFAOYSA-N

Classification Code

  • Antidepressant

Molecular Formula

  • C11-H12-N2-O2

Molecular Weight

  • 204.2278
 
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Names and Synonyms

Name of Substance

  • Thozalinone
  • Thozalinone [USAN]
  • Tozalinone [INN]

Synonyms

  • 2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one
  • 5-Phenyl-2-dimethylamino-2-oxazolin-4-one
  • BRN 0882816
  • CL 39808
  • NSC 170962
  • Stimsen
  • Thozalinone
  • Tozalinona
  • Tozalinona [INN-Spanish]
  • Tozalinone
  • Tozalinonum
  • Tozalinonum [INN-Latin]
  • UNII-68X5932947

Systematic Names

  • 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl-
  • 4(5H)-Oxazolone, 2-(dimethylamino)-5-phenyl-

Registry Numbers

CAS Registry Number

  • 655-05-0

FDA UNII

  • 68X5932947

System Generated Number

  • 0000655050

Structure Descriptors

InChI

1S/C11H12N2O2/c1-13(2)11-12-10(14)9(15-11)8-6-4-3-5-7-8/h3-7,9H,1-2H3

InChIKey

JJSHYECKYLDYAR-UHFFFAOYSA-N

Smiles

CN(C)C1=NC(=O)C(O1)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 7, Pg. 566, 1965.
mouse LD50 oral 570mg/kg (570mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 7, Pg. 566, 1965.
rat LD50 intraperitoneal 1240mg/kg (1240mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 7, Pg. 566, 1965.
rat LD50 oral > 3000mg/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 7, Pg. 566, 1965.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 134.5 deg C   EXP
log P (octanol-water) -0.230 (none)   EST
Atmospheric OH Rate Constant 7.88E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.