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Substance Name: Impromidine hydrochloride [USAN]
RN: 65573-02-6
UNII: E57WP5Y41J
InChIKey: HNQSXVXPLCRZNZ-UHFFFAOYSA-N

Note

  • A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.

Molecular Formula

  • C14-H23-N7-S.3Cl-H

Molecular Weight

  • 430.833
 

Classification Codes

  • Diagnostic Aid (Gastric Secretion Indicator)
  • Drug / Therapeutic Agent
  • Histamine H2 Receptor Antagonists
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Names and Synonyms

Name of Substance

  • Impromidine hydrochloride [USAN]

Synonyms

  • 1-(3-Imidazol-4-ylpropyl)-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine trihydrochloride
  • Guanidine, N-(3-(1H-imidazol-4-yl)propyl)-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-, trihydrochloride
  • Impromidine HCl
  • Impromidine hydrochloride
  • Impromidine trihydrochloride
  • SK&F 92676-A3
  • SKF 92676-A 3
  • UNII-E57WP5Y41J

Systematic Name

  • Guanidine, N-(3-(1H-imidazol-4-yl)propyl)-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-, trihydrochloride

Registry Numbers

CAS Registry Number

  • 65573-02-6

FDA UNII

  • E57WP5Y41J

Related Registry Number

  • 55273-05-7 (Parent)

System Generated Number

  • 0065573026

Molecular Formulas

Molecular Formula

  • C14-H23-N7-S.3Cl-H

Molecular Formula Fragments

  • C14-H23-N7-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H23N7S.3ClH/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12;;;/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18);3*1H

InChIKey

HNQSXVXPLCRZNZ-UHFFFAOYSA-N

Smiles

c1(c([nH]cn1)C)CSCCNC(NCCCc1c[nH]cn1)=N.Cl.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 27700ug/kg (27.7mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
JAT, Journal of Applied Toxicology. Vol. 2, Pg. 265, 1982.
mouse LD50 intravenous 9600ug/kg (9.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
JAT, Journal of Applied Toxicology. Vol. 2, Pg. 265, 1982.
rat LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD JAT, Journal of Applied Toxicology. Vol. 2, Pg. 265, 1982.