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Substance Name: Nintedanib [USAN:INN]
RN: 656247-17-5
UNII: G6HRD2P839
InChIKey: XZXHXSATPCNXJR-ZIADKAODSA-N

Notes

  • Boehringer Ingelheim's triple kinase inhibitor blocking VEGFR, PDGFR and FGFR.
  • NLM: Boehringer Ingelheims triple kinase inhibitor blocking VEGFR, PDGFR and FGFR.

    NCI: An orally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Multitargeted tyrosine kinase inhibitor BIBF 1120 selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. In addition, this agent also inhibits members of the Src family of tyrosine kinases, including Src, Lck, Lyn, and FLT-3 (fms-like tyrosine kinase 3). VEGFR, FGFR and PDGFR RTKs play key roles in tumor angiogenesis. NCI Thesaurus)

Molecular Formula

  • C31-H33-N5-O4

Molecular Weight

  • 539.6327
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors

Names and Synonyms

Name of Substance

  • Nintedanib [USAN:INN]

Synonyms

  • BIBF 1120
  • BIBF-1120
  • BIBF1120
  • HSDB 8339
  • Intedanib
  • Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate
  • Nintedanib
  • OFEV
  • UNII-G6HRD2P839
  • Vargatef

Registry Numbers

CAS Registry Number

  • 656247-17-5

FDA UNII

  • G6HRD2P839

Other Registry Number

  • 928326-83-4

System Generated Number

  • 0656247175

Structure Descriptors

InChI

1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-

InChIKey

XZXHXSATPCNXJR-ZIADKAODSA-N

Smiles

CN1CCN(CC1)CC(=O)N(C)c2ccc(cc2)N/C(=C\3/c4ccc(cc4NC3=O)C(=O)OC)/c5ccccc5