Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Nintedanib esylate [USAN]
RN: 656247-18-6
UNII: 42F62RTZ4G
InChIKey: MMMVNAGRWOJNMW-FJBFXRHMSA-N

Note

  • NLM: Boehringer Ingelheims triple kinase inhibitor blocking VEGFR, PDGFR and FGFR.

    NCI: An orally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Multitargeted tyrosine kinase inhibitor BIBF 1120 selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. In addition, this agent also inhibits members of the Src family of tyrosine kinases, including Src, Lck, Lyn, and FLT-3 (fms-like tyrosine kinase 3). VEGFR, FGFR and PDGFR RTKs play key roles in tumor angiogenesis. NCI Thesaurus)

Molecular Formula

  • C31-H33-N5-O4.C2-H6-O3-S

Molecular Weight

  • 649.7651
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Nintedanib esylate [USAN]

Synonyms

  • 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(((4-(methyl(2-(4-methyl-1-piperazinyl)acetyl)amino)phenyl)amino)phenylmethylene)-2-oxo-, methyl ester, (3Z)-, ethanesulfonate (1:1)
  • Nintedanib esylate
  • OFEV
  • UNII-42F62RTZ4G

Systematic Name

  • Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate

Registry Numbers

CAS Registry Number

  • 656247-18-6

FDA UNII

  • 42F62RTZ4G

System Generated Number

  • 0656247186

Structure Descriptors

InChI

1S/C31H33N5O4.C2H6O3S/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38;1-2-6(3,4)5/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38);2H2,1H3,(H,3,4,5)/b29-28-;

InChIKey

MMMVNAGRWOJNMW-FJBFXRHMSA-N

Smiles

CCS(=O)(=O)O.CN1CCN(CC1)CC(=O)N(C)c2ccc(cc2)N/C(=C\3/c4ccc(cc4NC3=O)C(=O)OC)/c5ccccc5