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Substance Name: Silymarin
RN: 65666-07-1
UNII: U946SH95EE
InChIKey: SEBFKMXJBCUCAI-WAABAYLZSA-N

Note

  • A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

Molecular Formula

  • Unspecified

Molecular Weight

  • 482.4388
 

Classification Codes

  • Mutation Data
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Milk thistle [NF]
  • Silymarin

MeSH Heading

  • Silymarin

Synonyms

  • CCRIS 7096
  • Flavobion
  • Legalon
  • Legalon 70
  • Milk thistle
  • Milk Thistle (Silybum marianum) Extract or Powder
  • Milk Thistle (Silybum marianum) Extract or Powder [seed]
  • Silybum marianum
  • Silymarin
  • UNII-U946SH95EE
  • Wild Artichoke

Systematic Name

  • Silymarin

Registry Numbers

CAS Registry Number

  • 65666-07-1

FDA UNII

  • U946SH95EE

System Generated Number

  • 0065666071

Structure Descriptors

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23-,24-,25+/m0/s1

InChIKey

SEBFKMXJBCUCAI-WAABAYLZSA-N

Smiles

COc1cc(ccc1O)[C@@H]2Oc3cc(ccc3O[C@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 1600mg/kg (1600mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2423725,