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Substance Name: Centazolone
RN: 65793-50-2
InChIKey: CZXUQBVMAUWSBX-UHFFFAOYSA-N

Note

  • Tranquillosedative drug with action similar to that of chlordiazepoxide.

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C12-H9-N3-O

Molecular Weight

  • 211.223
 
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Names and Synonyms

Name of Substance

  • Centazolone

Synonyms

  • 3-Amino-6,7-benzquinazole-4-one
  • 3-Aminobenzo(g)quinazolin-4(3H)-one
  • 3-Aminobenzo-6,7-quinazoline-4-one
  • Centazolone
  • Centzaolone
  • NSC 315852

Systematic Names

  • 3-Aminobenzo(g)quinazolin-4(3H)-one
  • Benzo(g)quinazolin-4(3H)-one, 3-amino-

Registry Numbers

CAS Registry Number

  • 65793-50-2

System Generated Number

  • 0065793502

Structure Descriptors

InChI

1S/C12H9N3O/c13-15-7-14-11-6-9-4-2-1-3-8(9)5-10(11)12(15)16/h1-7H,13H2

InChIKey

CZXUQBVMAUWSBX-UHFFFAOYSA-N

Smiles

c12c(n(cnc1cc1c(c2)cccc1)N)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intraperitoneal 54mg/kg (54mg/kg)   Indian Journal of Experimental Biology. Vol. 15, Pg. 1125, 1977.
man TDLo oral 1143ug/kg (1.143mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Indian Journal of Experimental Biology. Vol. 15, Pg. 1131, 1977.
monkey LD50 oral > 500mg/kg (500mg/kg)   Indian Journal of Experimental Biology. Vol. 15, Pg. 1125, 1977.
mouse LD50 intraperitoneal 160mg/kg (160mg/kg)   Indian Journal of Experimental Biology. Vol. 15, Pg. 1125, 1977.
mouse LD50 intravenous 60mg/kg (60mg/kg)   Indian Journal of Experimental Biology. Vol. 15, Pg. 1125, 1977.
mouse LD50 oral 525mg/kg (525mg/kg)   Indian Journal of Experimental Biology. Vol. 15, Pg. 1125, 1977.
rat LD50 intraperitoneal 266mg/kg (266mg/kg)   Indian Journal of Experimental Biology. Vol. 15, Pg. 1125, 1977.
rat LD50 oral 540mg/kg (540mg/kg)   Indian Journal of Experimental Biology. Vol. 15, Pg. 1125, 1977.