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Substance Name: BZ
RN: 6581-06-2
UNII: E69DLR7470
InChIKey: HGMITUYOCPPQLE-IBGZPJMESA-N

Note

  • A high-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies.

Molecular Formula

  • C21-H23-N-O3

Molecular Weight

  • 337.4167
 

Classification Codes

  • Chemical Warfare Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Human Data
  • Muscarinic Antagonists
  • Mutation Data
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • BZ
  • Quinuclidinyl benzilate

MeSH Heading

  • Quinuclidinyl benzilate

Synonyms

  • 3-(2,2-Diphenyl-2-hydroxyethanoyloxy)-quinuclidine
  • 3-Chinuclidylbenzilate
  • 3-Quinuclidinol benzilate
  • 3-Quinuclidinyl benzilate
  • 3-Quinuclidyl benzilate
  • Agent Buzz
  • Agent BZ
  • Buzz
  • BZ
  • BZ [anticholinergic]
  • CS 4030
  • EA 2277
  • HSDB 7533
  • NSC 173698
  • QNB
  • Quinuclidinyl benzilate
  • Ro 2-3308
  • UNII-E69DLR7470

Systematic Names

  • 1-Azabicyclo(2.2.2)octan-3-ol, benzilate (9CI)
  • Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 1-azabicyclo(2.2.2)oct-3-yl ester
  • Benzilic acid, 3-quinuclidinyl ester

Registry Numbers

CAS Registry Number

  • 6581-06-2

FDA UNII

  • E69DLR7470

Other Registry Numbers

  • 160902-51-2
  • 4478-53-9
  • 70135-17-0

System Generated Number

  • 0006581062

Structure Descriptors

InChI

1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/m0/s1

InChIKey

HGMITUYOCPPQLE-IBGZPJMESA-N

Smiles

OC(C(=O)O[C@H]1CN2CCC1CC2)(c3ccccc3)c4ccccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intramuscular 5ug/kg (0.005mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. 63, 1982.
human TDLo intravenous 4800ng/kg (0.0048mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC
"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. 63, 1982.
human TDLo oral 4500ng/kg (0.0045mg/kg) CARDIAC: CHANGE IN RATE "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. 63, 1982.
mouse LD50 intraperitoneal 103mg/kg (103mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 1(3), Pg. 3, 1967.
mouse LD50 intravenous 25mg/kg (25mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#11998,
mouse LDLo subcutaneous 100mg/kg (100mg/kg)   United States Patent Document. Vol. #3714357,
rat LDLo subcutaneous 265mg/kg (265mg/kg)   United States Patent Document. Vol. #3714357,