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Substance Name: Uracil [USAN:JAN]
RN: 66-22-8
UNII: 56HH86ZVCT
InChIKey: ISAKRJDGNUQOIC-UHFFFAOYSA-N

Note

  • One of four nucleotide bases in the nucleic acid RNA.

Molecular Formula

  • C4-H4-N2-O2

Molecular Weight

  • 112.0876
 

Classification Codes

  • Antineoplastic (Adjunct)
  • Mutation Data
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Uracil
  • Uracil [USAN:JAN]

MeSH Heading

  • Uracil

Synonyms

  • 2,4-Dihydroxypyrimidine
  • 2,4-Dioxopyrimidine
  • 2,4-Pyrimidinediol
  • 2,4-Pyrimidinedione
  • AI3-25470
  • BMS 205603-01
  • BMS-205603-01
  • CCRIS 3077
  • EINECS 200-621-9
  • Hybar X
  • NSC 3970
  • Pirod
  • Pyrod
  • RU 12709
  • SQ 6201
  • SQ 7726
  • SQ 8493
  • SQ-6201
  • SQ-7726
  • SQ-8493
  • UNII-56HH86ZVCT
  • Ura
  • Uracil

Systematic Names

  • 2,4(1H,3H)-Pyrimidinedione
  • Uracil

Registry Numbers

CAS Registry Number

  • 66-22-8

FDA UNII

  • 56HH86ZVCT

Other Registry Numbers

  • 138285-60-6
  • 144104-68-7
  • 153445-42-2
  • 42910-77-0
  • 4433-21-0
  • 4433-24-3
  • 51953-19-6
  • 766-19-8

System Generated Number

  • 0000066228

Structure Descriptors

InChI

1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChIKey

ISAKRJDGNUQOIC-UHFFFAOYSA-N

Smiles

c1c[nH]c(=O)[nH]c1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 5gm/kg (5000mg/kg)   Medicamentos de Actualidad. Vol. 21, Pg. 125, 1985.
mouse LD50 intraperitoneal 1513mg/kg (1513mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 207, Pg. 504, 1978.
mouse LD50 oral > 8gm/kg (8000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1009, 1980.
rabbit LD50 oral > 10gm/kg (10000mg/kg)   Medicamentos de Actualidad. Vol. 21, Pg. 125, 1985.
rat LD50 oral > 6gm/kg (6000mg/kg)   Medicamentos de Actualidad. Vol. 21, Pg. 125, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 338 deg C   EXP
pKa Dissociation Constant 9.45 (none)   EXP
log P (octanol-water) -1.07E+00 (none)   EXP
Water Solubility 3600 mg/L 25 EXP
Henry's Law Constant 1.91E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.77E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.