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Substance Name: Strychnine nitrate [NF]
RN: 66-32-0
UNII: O642E96711
InChIKey: PCGVPMHGSJFFTI-ZEYGOCRCSA-N

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Human Data
  • Rodenticide

Molecular Formula

  • C21-H22-N2-O2.H-N-O3

Molecular Weight

  • 397.4287
 
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Names and Synonyms

Name of Substance

  • Strychnine nitrate [NF]

Synonyms

  • EINECS 200-627-1
  • Strychnine nitrate
  • UNII-O642E96711

Systematic Names

  • Strychnidin-10-one mononitrate
  • Strychnine, mononitrate

Registry Numbers

CAS Registry Number

  • 66-32-0

FDA UNII

  • O642E96711

System Generated Number

  • 0000066320

Molecular Formulas

Molecular Formula

  • C21-H22-N2-O2.H-N-O3

Molecular Formula Fragments

  • C21-H22-N2-O2
  • COMPONENT
  • H-N-O3

Structure Descriptors

InChI

1S/C21H22N2O2.HNO3/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;2-1(3)4/h1-5,13,16-17,19-20H,6-11H2;(H,2,3,4)/t13-,16-,17-,19-,20-,21+;/m0./s1

InChIKey

PCGVPMHGSJFFTI-ZEYGOCRCSA-N

Smiles

c1ccc2c(c1)[C@]34CC[N@@]5[C@H]3C[C@@H]6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5.[N+](=O)(O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 2mg/kg (2mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
dog LDLo oral 1gm/kg (1000mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
guinea pig LDLo intraarterial 1200ug/kg (1.2mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intravenous 1mg/kg (1mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
human LDLo oral 500ug/kg (0.5mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
mouse LD50 oral 930ug/kg (0.93mg/kg)   Journal of Toxicology, Clinical Toxicology. Vol. 22, Pg. 425, 1984.
mouse LD50 unreported 900ug/kg (0.9mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 207, Pg. 688, 1949.
mouse LDLo intravenous 600ug/kg (0.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970.
mouse LDLo subcutaneous 2mg/kg (2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 458, 1967.
pig LDLo oral 20ug/kg (0.02mg/kg)   Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.
rabbit LD50 intravenous 250ug/kg (0.25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 1, 1958.
rat LD50 oral 16200ug/kg (16.2mg/kg)   Drugs in Japan Vol. 6, Pg. 377, 1982.
rat LDLo intravenous 600ug/kg (0.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970.
rat LDLo subcutaneous 3mg/kg (3mg/kg) BEHAVIORAL: TETANY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 187, Pg. 607, 1937.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 295 deg C   EXP
log P (octanol-water) 0.310 (none)   EST
Water Solubility 84.6 mg/L 25 EST
Vapor Pressure 1.47E-15 mm Hg 25 EST
Henry's Law Constant 1.19E-22 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.15E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.