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Substance Name: 1,10-Phenanthroline
RN: 66-71-7
UNII: W4X6ZO7939
InChIKey: DGEZNRSVGBDHLK-UHFFFAOYSA-N
Note
- Inhibits Zn-dependent metalloproteinases.
Molecular Formula
- C12-H8-N2
Molecular Weight
- 180.209
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Chelating Agents
- Cholinergic Agents
- Cholinesterase Inhibitors
- Cross-Linking Reagents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Indicators and Reagents
- Intercalating Agents
- Iron Chelating Agents
- Mutation Data
- Neurotransmitter Agents
- Protease Inhibitors
- Reproductive Effect
- Sequestering Agents
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Names and Synonyms
Name of Substance
- 1,10-Phenanthroline
Synonyms
- 1,10-Fenanthrolin
- 1,10-Fenanthrolin [Czech]
- 1,10-o-Phenanthroline
- 1,10-Phenanthroline
- 2-Phenanthroline
- 4,5-Diazaphenanthrene
- beta-Phenanthroline
- CCRIS 4855
- EINECS 200-629-2
- NSC 203545
- NSC 4265
- o-Phenanthroline
- Orthophenanthroline
- UNII-W4X6ZO7939
Systematic Names
- 1,10-Phenanthroline
- o-Phenanthroline
Superlist Name
- 1,10-Phenanthroline
Registry Numbers
CAS Registry Number
- 66-71-7
FDA UNII
- W4X6ZO7939
Related Registry Numbers
- 16561-55-0 (zinc salt)
- 21532-74-1 (monoperchlorate)
- 22802-96-6 (hydrochloride)
- 3829-86-5 (mono-hydrochloride)
System Generated Number
- 0000066717
Structure Descriptors
InChI
1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8HInChIKey
DGEZNRSVGBDHLK-UHFFFAOYSA-NSmiles
c12c3c(ccc1cccn2)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 75mg/kg (75mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976. |
| mouse | LD50 | intravenous | 18mg/kg (18mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 137, Pg. 1, 1962. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 117 | deg C | EXP | |
| Boiling Point | > 300 | deg C | EXP | |
| pKa Dissociation Constant | 4.27 | (none) | 20 | EXP |
| log P (octanol-water) | 1.78 | (none) | EXP | |
| Water Solubility | 2690 | mg/L | 25 | EXP |
| Vapor Pressure | 5.23E-05 | mm Hg | 25 | EST |
| Henry's Law Constant | 4.45E-10 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.00E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.