Important Announcement

X

ChemIDplus is moving to PubChem in December 2022.
Please see the NLM Technical Bulletin article for more information.

Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: 1,10-Phenanthroline
RN: 66-71-7
UNII: W4X6ZO7939
InChIKey: DGEZNRSVGBDHLK-UHFFFAOYSA-N

Note

  • Inhibits Zn-dependent metalloproteinases.

Molecular Formula

  • C12-H8-N2

Molecular Weight

  • 180.209
 

Classification Codes

  • Chelating Agents
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Cross-Linking Reagents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Indicators and Reagents
  • Intercalating Agents
  • Iron Chelating Agents
  • Mutation Data
  • Neurotransmitter Agents
  • Protease Inhibitors
  • Reproductive Effect
  • Sequestering Agents
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • 1,10-Phenanthroline

Synonyms

  • 1,10-Fenanthrolin
  • 1,10-Fenanthrolin [Czech]
  • 1,10-o-Phenanthroline
  • 1,10-Phenanthroline
  • 2-Phenanthroline
  • 4,5-Diazaphenanthrene
  • beta-Phenanthroline
  • CCRIS 4855
  • EINECS 200-629-2
  • NSC 203545
  • NSC 4265
  • o-Phenanthroline
  • Orthophenanthroline
  • UNII-W4X6ZO7939

Systematic Names

  • 1,10-Phenanthroline
  • o-Phenanthroline

Superlist Name

  • 1,10-Phenanthroline

Registry Numbers

CAS Registry Number

  • 66-71-7

FDA UNII

  • W4X6ZO7939

Related Registry Numbers

  • 16561-55-0 (zinc salt)
  • 21532-74-1 (monoperchlorate)
  • 22802-96-6 (hydrochloride)
  • 3829-86-5 (mono-hydrochloride)

System Generated Number

  • 0000066717

Structure Descriptors

InChI

InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H

InChIKey

DGEZNRSVGBDHLK-UHFFFAOYSA-N

Smiles

c1cnc2c(c1)ccc3cccnc23

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 75mg/kg (75mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES 		Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 137, Pg. 1, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 117 deg C   EXP
Boiling Point > 300 deg C   EXP
pKa Dissociation Constant 4.27 (none) 20 EXP
log P (octanol-water) 1.78 (none)   EXP
Water Solubility 2690 mg/L 25 EXP
Vapor Pressure 5.23E-05 mm Hg 25 EST
Henry's Law Constant 4.45E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.00E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.