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Substance Name: Mexamine hydrochloride
RN: 66-83-1
UNII: 4265IB6QEK
InChIKey: TXVAYRSEKRMEIF-UHFFFAOYSA-N

Note

  • Serotonin derivative proposed as potentiator for hypnotics and sedatives.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C11-H14-N2-O.Cl-H

Molecular Weight

  • 226.7055
 
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Names and Synonyms

Results Name

  • Mexamine hydrochloride

Name of Substance

  • 5-Methoxytryptamine hydrochloride

Synonyms

  • 1,6-Hexanediamine, N,N'-bis(o-chlorobenzyl)-, dihydrochloride
  • 1H-Indole-3-ethanamine, 5-methoxy-, monohydrochloride
  • 3-(2-Aminoethyl)-5-methoxyindole hydrochloride
  • 5-Methoxytryptamine hydrochloride
  • EINECS 200-637-6
  • Mexamine HCl
  • Mexamine hydrochloride
  • UNII-4265IB6QEK

Systematic Names

  • 5-Methoxy-1H-indole-3-ethylamine monohydrochloride
  • Indole, 3-(2-aminoethyl)-5-methoxy-, hydrochloride

Registry Numbers

CAS Registry Number

  • 66-83-1

FDA UNII

  • 4265IB6QEK

System Generated Number

  • 0000066831

Molecular Formulas

Molecular Formula

  • C11-H14-N2-O.Cl-H

Molecular Formula Fragments

  • C11-H14-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C11H14N2O.ClH/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11;/h2-3,6-7,13H,4-5,12H2,1H3;1H

InChIKey

TXVAYRSEKRMEIF-UHFFFAOYSA-N

Smiles

COc1ccc2c(c1)c(c[nH]2)CCN.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 2500ug/kg (2.5mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: OTHER CHANGES
Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963.
mouse LD50 intraperitoneal 227mg/kg (227mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1620, 1974.
mouse LD50 intravenous 103mg/kg (103mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 23, Pg. T125, 1964.
mouse LD50 oral 580mg/kg (580mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 23, Pg. T125, 1964.
mouse LD50 subcutaneous 620mg/kg (620mg/kg)   Russian Pharmacology and Toxicology Vol. 35, Pg. 2, 1972.
rabbit LDLo intravenous 75mg/kg (75mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963.
rat LDLo intravenous 6mg/kg (6mg/kg)   Russian Pharmacology and Toxicology Vol. 33, Pg. 246, 1970.