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Substance Name: 5-Fluorouracil glucuronide
RN: 66048-45-1
InChIKey: LKZGKOYOKVWGFN-UQGZVRACSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H11-F-N2-O8

Molecular Weight

  • 306.2009
 
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Names and Synonyms

Name of Substance

  • 5-Fluorouracil glucuronide

Synonyms

  • 1-Deoxy-1-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)-beta-D-glucopyranuronic acid
  • 1-Deoxy-1-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-beta-D-glucopyranuronic acid
  • 5-Fluouracil N-glucuronide
  • 5-FU N-glucuronide
  • Acido 1-deossi-1-(3,4-diidro-2,4-diosso-5-fluoro-1(2H)pirimidinil)glucopiranuronico
  • Acido 1-deossi-1-(3,4-diidro-2,4-diosso-5-fluoro-1(2H)pirimidinil)glucopiranuronico [Italian]
  • FU-N-G
  • MG 6758

Systematic Name

  • beta-D-Glucopyranuronic acid, 1-deoxy-1-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-

Registry Numbers

CAS Registry Number

  • 66048-45-1

System Generated Number

  • 0066048451

Structure Descriptors

InChI

1S/C10H11FN2O8/c11-2-1-13(10(20)12-7(2)17)8-5(16)3(14)4(15)6(21-8)9(18)19/h1,3-6,8,14-16H,(H,18,19)(H,12,17,20)/t3-,4-,5+,6-,8+/m0/s1

InChIKey

LKZGKOYOKVWGFN-UQGZVRACSA-N

Smiles

c1c(c(=O)[nH]c(=O)n1[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O)O)O)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 1883mg/kg (1883mg/kg)   Bollettino Chimico Farmaceutico. Vol. 118, Pg. 721, 1979.
mouse LD50 intravenous 5gm/kg (5000mg/kg)   Gann. Japanese Journal of Cancer Research. Vol. 69, Pg. 283, 1978.