|
|
|
Substance Name: Nimodipine [USAN:USP:INN:BAN]
RN: 66085-59-4
UNII: 57WA9QZ5WH
InChIKey: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Note
- A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
Molecular Formula
- C21-H26-N2-O7
Molecular Weight
- 418.4434
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Membrane Transport Modulators
- Reproductive Effect
- Vasodilator
- Vasodilator Agents
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Nimodipine
- Nimodipine [USAN:USP:INN:BAN]
MeSH Heading
- Nimodipine
Synonyms
- BAY e 9736
- BRN 0459792
- DRG-0139
- EINECS 266-127-0
- Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
- Nimodipine
- Nimodipino
- Nimodipino [INN-Spanish]
- Nimodipinum
- Nimodipinum [INN-Latin]
- Nimotop
- Nymalize
- Periplum
- UNII-57WA9QZ5WH
Systematic Names
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
- Nimodipine
Superlist Name
- Nimodipine
Registry Numbers
CAS Registry Number
- 66085-59-4
FDA UNII
- 57WA9QZ5WH
System Generated Number
- 0066085594
Structure Descriptors
InChI
1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3InChIKey
UIAGMCDKSXEBJQ-UHFFFAOYSA-NSmiles
CC1=C(C(C(=C(N1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 4mg/kg (4mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986. | |
| dog | LD50 | oral | 1gm/kg (1000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. | |
| mouse | LD50 | intravenous | 26200ug/kg (26.2mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. | |
| mouse | LD50 | oral | 940mg/kg (940mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
| mouse | LD50 | subcutaneous | 9500mg/kg (9500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
| rabbit | LD50 | intravenous | 2500ug/kg (2.5mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986. | |
| rabbit | LD50 | oral | 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986. | |
| rat | LD50 | intravenous | 5mg/kg (5mg/kg) | Archives of Toxicology. Vol. 54, Pg. 275, 1983. | |
| rat | LD50 | oral | 2738mg/kg (2738mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
| rat | LD50 | subcutaneous | 4234mg/kg (4234mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 3.05 | (none) | EXP | |
| Water Solubility | 24.3 | mg/L | 25 | EST |
| Vapor Pressure | 5.10E-10 | mm Hg | 25 | EST |
| Henry's Law Constant | 2.00E-15 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.25E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.