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Substance Name: Nimodipine [USAN:USP:INN:BAN]
RN: 66085-59-4
UNII: 57WA9QZ5WH
InChIKey: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Note
- A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
Molecular Formula
- C21-H26-N2-O7
Molecular Weight
- 418.4434
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Membrane Transport Modulators
- Reproductive Effect
- Vasodilator
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Nimodipine
- Nimodipine [USAN:USP:INN:BAN]
MeSH Heading
- Nimodipine
Synonyms
- BAY e 9736
- BRN 0459792
- DRG-0139
- EINECS 266-127-0
- Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
- Nimodipine
- Nimodipino
- Nimodipino [INN-Spanish]
- Nimodipinum
- Nimodipinum [INN-Latin]
- Nimotop
- NSC 758476
- Nymalize
- Periplum
- UNII-57WA9QZ5WH
Systematic Names
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
- Nimodipine
Superlist Name
- Nimodipine
Registry Numbers
CAS Registry Number
- 66085-59-4
FDA UNII
- 57WA9QZ5WH
System Generated Number
- 0066085594
Structure Descriptors
InChI
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3InChIKey
UIAGMCDKSXEBJQ-UHFFFAOYSA-NSmiles
COCCOC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 4mg/kg (4mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986. | |
dog | LD50 | oral | 1gm/kg (1000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. | |
mouse | LD50 | intravenous | 26200ug/kg (26.2mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. | |
mouse | LD50 | oral | 940mg/kg (940mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
mouse | LD50 | subcutaneous | 9500mg/kg (9500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
rabbit | LD50 | intravenous | 2500ug/kg (2.5mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986. | |
rabbit | LD50 | oral | 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986. | |
rat | LD50 | intravenous | 5mg/kg (5mg/kg) | Archives of Toxicology. Vol. 54, Pg. 275, 1983. | |
rat | LD50 | oral | 2738mg/kg (2738mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. | |
rat | LD50 | oral | 2738mg/kg (2738mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
rat | LD50 | subcutaneous | 4234mg/kg (4234mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 3.05 | (none) | EXP | |
Water Solubility | 24.3 | mg/L | 25 | EST |
Vapor Pressure | 5.10E-10 | mm Hg | 25 | EST |
Henry's Law Constant | 2.00E-15 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.25E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.