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Substance Name: Pergolide [INN:BAN]
RN: 66104-22-1
UNII: 24MJ822NZ9
InChIKey: YEHCICAEULNIGD-MZMPZRCHSA-N

Note

  • A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.

Molecular Formula

  • C19-H26-N2-S

Molecular Weight

  • 314.494
 

Classification Codes

  • Dopamine Agents
  • Dopamine Agonists
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Pergolide
  • Pergolide [INN:BAN]

MeSH Heading

  • Pergolide

Synonyms

  • D-8beta-[(Methylthio)methyl]-6-propylergoline
  • LY 141B
  • Pergolida
  • Pergolida [INN-Spanish]
  • Pergolide
  • Pergolidum
  • Pergolidum [INN-Latin]
  • Permax
  • UNII-24MJ822NZ9

Systematic Name

  • Ergoline, 8-((methylthio)methyl)-6-propyl-, (8beta)-

Registry Numbers

CAS Registry Number

  • 66104-22-1

FDA UNII

  • 24MJ822NZ9

Related Registry Number

  • 66104-23-2 (mesylate)

System Generated Number

  • 0066104221

Structure Descriptors

InChI

1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1

InChIKey

YEHCICAEULNIGD-MZMPZRCHSA-N

Smiles

c12c3[C@@H]4[C@H]([N@@](C[C@@H](C4)CSC)CCC)Cc1c[nH]c2ccc3

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 207.5 deg C   EXP
log P (octanol-water) 4.020 (none)   EST
Atmospheric OH Rate Constant 3.37E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.