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Substance Name: Ifenprodil tartrate (2:1)
RN: 66157-43-5
InChIKey: DMPRDSPPYMZQBT-CEAXSRTFSA-L

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C42-H54-N2-O4.C4-H6-O6

Molecular Weight

  • 798.968
 
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Names and Synonyms

Results Name

  • Ifenprodil tartrate (2:1)

Synonyms

  • 2-(4-Benzyl-piperidino)-1-(4-hydroxyphenyl)-1-propanol tartrate (2:1)
  • 4-Benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidine-ethanol-(L)-(+)-tartrate
  • 4-Benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol tartrate
  • Cerocral
  • Dilvax
  • Ifenprodil L-(+)-tartrate
  • Ifenprodil L-(+)-tartrate (2:1)
  • Ifenprodil tartrate
  • Ifenprodil tartrate (2:1)
  • Piperidineethanol, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-, tartrate (2:1)
  • Vadilex
  • Validex

Systematic Name

  • 1-Piperidineethanol, 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-, tartrate (salt) (2:1)

Registry Numbers

CAS Registry Number

  • 66157-43-5

System Generated Number

  • 0066157435

Molecular Formulas

Molecular Formula

  • C42-H54-N2-O4.C4-H6-O6

Molecular Formula Fragments

  • C4-H6-O6
  • C42-H54-N2-O4
  • COMPONENT

Structure Descriptors

InChI

1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/p-2/t;;1-,2-/m..1/s1

InChIKey

DMPRDSPPYMZQBT-CEAXSRTFSA-L

Smiles

C([C@@H]([C@H](C(=O)[O-])O)O)(=O)[O-].N1(CCC(CC1)Cc1ccccc1)[C@@H]([C@@H](c1ccc(O)cc1)O)C.N1(CCC(Cc2ccccc2)CC1)[C@@H](C)[C@@H](c1ccc(cc1)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 34200ug/kg (34.2mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
dog LD50 oral 461mg/kg (461mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 415, 1977.
mouse LD50 intramuscular 222mg/kg (222mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
mouse LD50 intraperitoneal 120mg/kg (120mg/kg)   United States Patent Document. Vol. #3509164,
mouse LD50 intravenous 44mg/kg (44mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
mouse LD50 oral 17mg/kg (17mg/kg)   United States Patent Document. Vol. #3509164,
rabbit LD50 intramuscular 77600ug/kg (77.6mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
rabbit LD50 intravenous 18300ug/kg (18.3mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
rabbit LD50 oral 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
rat LD50 intramuscular 240mg/kg (240mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
rat LD50 intraperitoneal 138mg/kg (138mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.
rat LD50 intravenous 44mg/kg (44mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
rat LD50 oral 538mg/kg (538mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 10, Pg. 785, 1975.