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Substance Name: Cefotiam hydrochloride [USAN:USP:JAN]
RN: 66309-69-1
UNII: H7V12WDZ93
InChIKey: BWRRTAXZCKVRON-DGPOFWGLSA-N

Note

  • One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

Molecular Formula

  • C18-H23-N9-O4-S3.2Cl-H

Molecular Weight

  • 598.558
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Cefotiam hydrochloride [USAN:USP:JAN]

Synonyms

  • (6R,7R)-7-(2-(2-Amino-4-thiazolyl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid dihydrochloride
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)-amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)-thio)methyl)-8-oxo-, hydrochloride, (6R-trans)-
  • 7(R)-(2-(2-Amino-4-thiazolyl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid dihydrochloride
  • Abbott 48999
  • Abbott-48999
  • Cefotiam dihydrochloride
  • Cefotiam HCl
  • Cefotiam hydrochloride
  • Ceradon
  • CGP-14221/E
  • EINECS 266-312-6
  • Halospor
  • Pansporin
  • Pansporin Ampullen
  • Pansporine
  • SCE 963
  • Spizef
  • UNII-H7V12WDZ93

Systematic Names

  • (6R-trans)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid dihydrochloride
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, dihydrochloride, (6R-trans)-

Registry Numbers

CAS Registry Number

  • 66309-69-1

FDA UNII

  • H7V12WDZ93

System Generated Number

  • 0066309691

Molecular Formulas

Molecular Formula

  • C18-H23-N9-O4-S3.2Cl-H

Molecular Formula Fragments

  • C18-H23-N9-O4-S3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1

InChIKey

BWRRTAXZCKVRON-DGPOFWGLSA-N

Smiles

N12[C@@H]([C@@H](NC(Cc3nc(N)sc3)=O)C2=O)SCC(=C1C(O)=O)CSc1n(nnn1)CCN(C)C.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 3820ug/kg (3.82mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 439, 1981.
mouse LD50 oral > 20gm/kg (20000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 439, 1981.
mouse LD50 subcutaneous 7800mg/kg (7800mg/kg)   Drugs in Japan Vol. 6, Pg. 411, 1982.
rat LD50 intravenous 3680mg/kg (3680mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
rat LD50 oral > 20gm/kg (20000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 439, 1981.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 411, 1982.