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Substance Name: Ranitidine [USAN:INN:BAN]
RN: 66357-35-5
UNII: 884KT10YB7
InChIKey: VMXUWOKSQNHOCA-UHFFFAOYSA-N
Note
- A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
Molecular Formula
- C13-H22-N4-O3-S
Molecular Weight
- 314.4078
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antagonist
- Antagonist (to Histamine H2 Receptors)
- Anti-Ulcer Agents
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H2 Antagonists
- Human Data
- Neurotransmitter Agents
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Names and Synonyms
Name of Substance
- Ranitidine
- Ranitidine [USAN:INN:BAN]
MeSH Heading
- Ranitidine
Synonyms
- 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
- Achedos
- Acid reducer
- Acidex
- Atural
- Axoban
- Coralen
- Curan
- Duractin
- EC 266-332-5
- EINECS 266-332-5
- Ezopta
- Gastrial
- Gastrosedol
- HSDB 3925
- Istomar
- Logast
- Major ranitidine
- Mauran
- Microtid
- N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
- NSC 757851
- Ptinolin
- Quantor
- Quicran
- Radinat
- Randin
- Ranidine
- Ranin
- Raniogas
- Ranisen
- Raniter
- Ranitidina
- Ranitidina [INN-Spanish]
- Ranitidine
- Ranitidinum
- Ranitidinum [INN-Latin]
- Ranitiget
- Rantacid
- Ratic
- Raticina
- RND
- Sampep
- Taural
- Topcare jeartburn relief
- Ul-Pep
- Ulceranin
- UNII-884KT10YB7
- Up and up acod redicer
- Urantac
- Verlost
- Vesyca
- Vizerul
- Weichilin
- Weidos
- Xanidine
- Zantab
- Zantadin
Systematic Names
- 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
- Ranitidine
Registry Numbers
CAS Registry Number
- 66357-35-5
FDA UNII
- 884KT10YB7
Related Registry Number
- 66357-59-3 (hydrochloride)
System Generated Number
- 0066357355
Structure Descriptors
InChI
InChI=1S/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3InChIKey
VMXUWOKSQNHOCA-UHFFFAOYSA-NSmiles
CNC(=C[N+](=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 4286ug/kg/2D- (4.286mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | American Journal of Emergency Medicine. Vol. 17, Pg. 258, 1999. |
man | TDLo | oral | 60mg/kg/14D-I (60mg/kg) | LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" LIVER: "JAUNDICE, CHOLESTATIC" | American Journal of Gastroenterology. Vol. 93, Pg. 822, 1998. |
mouse | LD50 | intramuscular | 280mg/kg (280mg/kg) | United States Patent Document. Vol. #4613602, | |
mouse | LD50 | intravenous | 80mg/kg (80mg/kg) | United States Patent Document. Vol. #4613602, | |
mouse | LD50 | oral | 884mg/kg (884mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 749, 1990. | |
rat | LD50 | intramuscular | 2018mg/kg (2018mg/kg) | United States Patent Document. Vol. #4613602, | |
rat | LD50 | intravenous | 93mg/kg (93mg/kg) | United States Patent Document. Vol. #4613602, | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #4613602, | |
women | TDLo | oral | 12mg/kg/2D-I (12mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE" BLOOD: OTHER CHANGES KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS | American Journal of Emergency Medicine. Vol. 12, Pg. 67, 1994. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 69-70 | deg C | EXP | |
log P (octanol-water) | 0.27 | (none) | EXP | |
Water Solubility | 2.47E+04 | mg/L | 25 | EST |
Vapor Pressure | 1.20E-07 | mm Hg | 25 | EST |
Henry's Law Constant | 3.42E-15 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.62E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.