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Substance Name: Ranitidine [USAN:INN:BAN]
RN: 66357-35-5
UNII: 884KT10YB7
InChIKey: VMXUWOKSQNHOCA-UHFFFAOYSA-N

Note

  • A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

Molecular Formula

  • C13-H22-N4-O3-S

Molecular Weight

  • 314.4078
 

Classification Codes

  • Antagonist
  • Antagonist (to Histamine H2 Receptors)
  • Anti-Ulcer Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H2 Antagonists
  • Human Data
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Ranitidine
  • Ranitidine [USAN:INN:BAN]

MeSH Heading

  • Ranitidine

Synonyms

  • 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
  • Achedos
  • Acid reducer
  • Acidex
  • Atural
  • Axoban
  • Coralen
  • Curan
  • Duractin
  • EC 266-332-5
  • EINECS 266-332-5
  • Ezopta
  • Gastrial
  • Gastrosedol
  • HSDB 3925
  • Istomar
  • Logast
  • Major ranitidine
  • Mauran
  • Microtid
  • N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
  • Ptinolin
  • Quantor
  • Quicran
  • Radinat
  • Randin
  • Ranidine
  • Ranin
  • Raniogas
  • Ranisen
  • Raniter
  • Ranitidina
  • Ranitidina [INN-Spanish]
  • Ranitidine
  • Ranitidinum
  • Ranitidinum [INN-Latin]
  • Ranitiget
  • Rantacid
  • Ratic
  • Raticina
  • RND
  • Sampep
  • Taural
  • Topcare jeartburn relief
  • Ul-Pep
  • Ulceranin
  • UNII-884KT10YB7
  • Up and up acod redicer
  • Urantac
  • Verlost
  • Vesyca
  • Vizerul
  • Weichilin
  • Weidos
  • Xanidine
  • Zantab
  • Zantadin

Systematic Names

  • 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
  • Ranitidine

Registry Numbers

CAS Registry Number

  • 66357-35-5

FDA UNII

  • 884KT10YB7

Related Registry Number

  • 66357-59-3 (hydrochloride)

System Generated Number

  • 0066357355

Structure Descriptors

InChI

1S/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3

InChIKey

VMXUWOKSQNHOCA-UHFFFAOYSA-N

Smiles

CNC(=C[N+](=O)[O-])NCCSCc1oc(CN(C)C)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 4286ug/kg/2D- (4.286mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Emergency Medicine. Vol. 17, Pg. 258, 1999.
man TDLo oral 60mg/kg/14D-I (60mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

LIVER: "JAUNDICE, CHOLESTATIC"
American Journal of Gastroenterology. Vol. 93, Pg. 822, 1998.
mouse LD50 intramuscular 280mg/kg (280mg/kg)   United States Patent Document. Vol. #4613602,
mouse LD50 intravenous 80mg/kg (80mg/kg)   United States Patent Document. Vol. #4613602,
mouse LD50 oral 884mg/kg (884mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 749, 1990.
rat LD50 intramuscular 2018mg/kg (2018mg/kg)   United States Patent Document. Vol. #4613602,
rat LD50 intravenous 93mg/kg (93mg/kg)   United States Patent Document. Vol. #4613602,
rat LD50 oral > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4613602,
women TDLo oral 12mg/kg/2D-I (12mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE"

BLOOD: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
American Journal of Emergency Medicine. Vol. 12, Pg. 67, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 69-70 deg C   EXP
log P (octanol-water) 0.27 (none)   EXP
Water Solubility 2.47E+04 mg/L 25 EST
Vapor Pressure 1.20E-07 mm Hg 25 EST
Henry's Law Constant 3.42E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.62E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.