Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: Ranitidine Hydrochloride [USP:JAN]
RN: 66357-59-3
UNII: BK76465IHM
InChIKey: GGWBHVILAJZWKJ-UHFFFAOYSA-N

Note

  • A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

Molecular Formula

  • C13-H22-N4-O3-S.Cl-H

Molecular Weight

  • 350.8687
 

Classification Codes

  • Antagonist
  • Antagonist (to Histamine H2 Receptors)
  • Histamine H2 Receptor Antagonists
  • Human Data

Names and Synonyms

Name of Substance

  • Ranitidine Hydrochloride [USP:JAN]

Synonyms

  • 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-, monohydrochloride
  • AH 19065
  • Alquen
  • Alter-H2
  • Alvidina
  • Apo-Ranitidin
  • Artomil
  • Azuranit
  • CCRIS 5268
  • Coralen
  • Coralen [inj.]
  • Digestosan
  • EINECS 266-333-0
  • Ergan
  • Esofex
  • Fendibina
  • Gastridina
  • Gastrolav
  • Kuracid
  • Label
  • Lake
  • Logat
  • Mideran
  • N-(2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine, hydrochloride
  • Neugal
  • Noktome
  • Normon
  • Novo-Radinine
  • Nu-Ranit
  • Pep-Rani
  • Quadrin
  • Quantor
  • Quantor [inj.]
  • Radin
  • RAN
  • Ran H2
  • Ran Lich
  • Rani 2
  • Rani AbZ
  • Rani-BASF
  • Rani-nerton
  • Rani-Puren
  • Rani-Q
  • Rani-Sanorania
  • Raniberl
  • Raniberta
  • Ranibloc
  • ranic
  • Ranicux
  • Ranidil
  • Ranidin
  • Ranidura
  • Ranifur
  • Ranifur [inj.]
  • Ranigasan
  • Ranigast
  • Ranigen
  • Ranilonga
  • Ranimerck
  • Ranisan
  • Ranitab
  • Ranitic
  • Ranitidin
  • Ranitidin 1A Pharma
  • Ranitidin AL
  • Ranitidin Arcana
  • Ranitidin Atid
  • Ranitidin AWD
  • Ranitidin Basics
  • Ranitidin Duncan
  • Ranitidin Dyna
  • Ranitidin Helvepharm
  • Ranitidin Heumann
  • Ranitidin Hexal
  • Ranitidin Merck
  • Ranitidin Millet
  • Ranitidin NM
  • Ranitidin Normon
  • Ranitidin PB
  • Ranitidin Stada
  • Ranitidin von ct
  • Ranitidin-Cophar
  • Ranitidin-Isis
  • Ranitidin-ratiopharm
  • Ranitidina predilu Grif
  • Ranitidina Tamarang
  • Ranitidine
  • Ranitidine hydrochloride
  • Ranitin
  • Ranitine
  • Ranobel
  • Ranuber
  • Regalil
  • Renatac
  • Rozon
  • Rubiulcer
  • Santanol
  • Serviradine
  • Tanidina
  • Toriol
  • Trigger [Drug]
  • Ulcecur
  • Ulcirex
  • Ulcodin
  • Ulcolind Rani
  • Ulcosan
  • Ulsaven
  • UNII-BK76465IHM
  • Viserul
  • Zandid
  • Zantac
  • Zantac 150
  • Zantac 25
  • Zantac 300
  • Zantac 75
  • Zantac efferdose
  • Zantac in plastic container
  • Zantarac

Systematic Names

  • 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-, monohydrochloride
  • N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitrovinylidenediamine hydrochloride
  • Ranitidine hydrochloride

Registry Numbers

CAS Registry Number

  • 66357-59-3

FDA UNII

  • BK76465IHM

Related Registry Number

  • 66357-35-5 (Parent)

System Generated Number

  • 0066357593

Molecular Formulas

Molecular Formula

  • C13-H22-N4-O3-S.Cl-H

Molecular Formula Fragments

  • C13-H22-N4-O3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H

InChIKey

GGWBHVILAJZWKJ-UHFFFAOYSA-N

Smiles

Cl.CNC(=C[N+](=O)[O-])NCCSCc1oc(CN(C)C)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 2400mg/kg/43W (2400mg/kg) SKIN AND APPENDAGES (SKIN): SWEATING: OTHER

CARDIAC: PULSE RATE

BEHAVIORAL: COMA		 American Journal of Diseases of Children. Vol. 139, Pg. 442, 1985.
dog LDLo oral 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA		 Journal of Toxicological Sciences. Vol. 8(Suppl,
man TDLo intravenous 714mg/kg/5M-C (714mg/kg) CARDIAC: CHANGE IN RATE American Journal of Gastroenterology. Vol. 83, Pg. 332, 1988.
man TDLo oral 8571ug/kg/2D- (8.571mg/kg) BLOOD: EOSINOPHILIA

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 American Journal of Kidney Diseases. Vol. 22, Pg. 337, 1993.
man TDLo oral 30mg/kg/1W-I (30mg/kg) BEHAVIORAL: HEADACHE New England Journal of Medicine. Vol. 310, Pg. 1602, 1984.
man TDLo oral 87mg/kg/4D-I (87mg/kg) CARDIAC: PULSE RATE

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Annals of Internal Medicine. Vol. 108, Pg. 493, 1988.
mouse LD50 intramuscular 400mg/kg (400mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
mouse LD50 intraperitoneal 300mg/kg (300mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
mouse LD50 intravenous 60mg/kg (60mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Toxicological Sciences. Vol. 8(Suppl,
mouse LD50 oral 1100mg/kg (1100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Journal of Toxicological Sciences. Vol. 8(Suppl,
mouse LD50 subcutaneous 630mg/kg (630mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rabbit LD50 intravenous 109mg/kg (109mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rabbit LD50 oral 2500mg/kg (2500mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rat LD50 intramuscular 1530mg/kg (1530mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rat LD50 intraperitoneal 441mg/kg (441mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rat LD50 intravenous 85mg/kg (85mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Toxicological Sciences. Vol. 8(Suppl,
rat LD50 oral 4190mg/kg (4190mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 147, 1983.
rat LD50 subcutaneous 1700mg/kg (1700mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
women TDLo intravenous 27mg/kg/8D-I (27mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Archives of Internal Medicine. Vol. 152, Pg. 2325, 1992.
women TDLo multiple routes 174mg/kg/33D- (174mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS		 American Journal of Kidney Diseases. Vol. 22, Pg. 333, 1993.
women TDLo oral 3mg/kg (3mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 New England Journal of Medicine. Vol. 310, Pg. 1601, 1984.
women TDLo oral 9mg/kg/36H-I (9mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" American Journal of Psychiatry. Vol. 143, Pg. 257, 1985.
women TDLo oral 12mg/kg/2D-I (12mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Allergy. Vol. 51, Pg. 659, 1996.