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Substance Name: Lotrifen [INN]
RN: 66535-86-2
UNII: K6J75G277H
InChIKey: DGWUVKLBXCWNTA-UHFFFAOYSA-N

Note

  • Has been used in dogs.

Classification Code

  • Reproductive Effect

Molecular Formula

  • C16-H10-Cl-N3

Molecular Weight

  • 279.729
 
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Names and Synonyms

Name of Substance

  • Lotrifen
  • Lotrifen [INN]

Synonyms

  • 2-(4-Chlorophenyl)-(1,2,4)triazolo(5,1-a)isoquinoline
  • 2-(p-Chlorophenyl)-s-triazolo(5,1-a)isoquinoline
  • BRN 0535459
  • Canocenta
  • DL 717
  • DL 717-IT
  • DL 717IT
  • EINECS 266-394-3
  • L 12717
  • Lotrifen
  • Lotrifene
  • Lotrifene [French]
  • Lotrifeno
  • Lotrifeno [Spanish]
  • Lotrifenum
  • Lotrifenum [Latin]
  • Privaprol
  • UNII-K6J75G277H

Systematic Names

  • (1,2,4)Triazolo(5,1-a)isoquinoline, 2-(4-chlorophenyl)-
  • (1,2,4)Triazolo(5,1-a)isoquinoline, 2-(4-chlorophenyl)- (9CI)
  • 2-(p-Chlorophenyl)-s-triazolo(5,1-a)isoquinoline
  • Lotrifen
  • s-Triazolo(5,1-a)isoquinoline, 2-(p-chlorophenyl)-

Registry Numbers

CAS Registry Number

  • 66535-86-2

FDA UNII

  • K6J75G277H

System Generated Number

  • 0066535862

Structure Descriptors

InChI

1S/C16H10ClN3/c17-13-7-5-12(6-8-13)15-18-16-14-4-2-1-3-11(14)9-10-20(16)19-15/h1-10H

InChIKey

DGWUVKLBXCWNTA-UHFFFAOYSA-N

Smiles

n1n2ccc3c(c2nc1c1ccc(cc1)Cl)cccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intramuscular 75mg/kg (75mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Medicamentos de Actualidad. Vol. 23, Pg. 75, 1987.
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg)   Medicamentos de Actualidad. Vol. 23, Pg. 75, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 239 deg C   EXP
log P (octanol-water) 4.530 (none)   EST
Atmospheric OH Rate Constant 1.06E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.