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Substance Name: Colforsin [USAN:INN]
RN: 66575-29-9
UNII: 1F7A44V6OU
InChIKey: OHCQJHSOBUTRHG-KGGHGJDLSA-N

Note

  • Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

Molecular Formula

  • C22-H34-O7

Molecular Weight

  • 410.5036
 

Classification Codes

  • Adjuvants, Immunologic
  • Anti-Asthmatic Agents
  • Antiglaucoma Agent
  • Autonomic Agents
  • Bronchodilator Agents
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Natural Product
  • Peripheral Nervous System Agents
  • Protective Agents
  • Respiratory System Agents
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Colforsin [USAN:INN]

MeSH Heading

  • Colforsin

Synonyms

  • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate
  • 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-
  • 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one
  • Boforsin
  • Coleonol
  • Colforsin
  • Colforsina
  • Colforsina [Spanish]
  • Colforsine
  • Colforsine [French]
  • Colforsinum
  • Colforsinum [Latin]
  • EINECS 266-410-9
  • Forskohlii Root Extract (ForsLean)(20% forskohlin)
  • Forskolin
  • ForsLean
  • HL 362
  • L 75 1362B
  • M 410
  • NSC 357088
  • NSC 375489
  • UNII-1F7A44V6OU

Systematic Names

  • 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-
  • 1H-Naphtho(2,1-b)pyran-1-one, dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-
  • Colforsin

Registry Numbers

CAS Registry Number

  • 66575-29-9

FDA UNII

  • 1F7A44V6OU

Other Registry Number

  • 64657-11-0

System Generated Number

  • 0066575299

Structure Descriptors

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChIKey

OHCQJHSOBUTRHG-KGGHGJDLSA-N

Smiles

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 68mg/kg (68mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Ethnopharmacology. Vol. 3, Pg. 1, 1981.
mouse LD50 oral 3100mg/kg (3100mg/kg)   Medicinal Research Reviews. Vol. 3, Pg. 201, 1983.
rat LD50 intraperitoneal 92mg/kg (92mg/kg)   Journal of Medicinal Chemistry. Vol. 31, Pg. 1872, 1988.
rat LD50 oral 2550mg/kg (2550mg/kg)   Medicinal Research Reviews. Vol. 3, Pg. 201, 1983.