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Substance Name: Platyphylline hydrochloride
RN: 66641-38-1
InChIKey: PDTRRWDNKPZFEY-UKADVOBOSA-N

Classification Codes

  • Mutation Data
  • Natural Product

Molecular Formula

  • C18-H27-N-O5.Cl-H

Molecular Weight

  • 373.8742
 
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Names and Synonyms

Synonyms

  • Platiphillin hydrochloride
  • Platiphyllin hydrochloride
  • Platyphylline HCl
  • Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, hydrochloride, (1-alpha)-

Systematic Name

  • Platyphylline hydrochloride

Registry Numbers

CAS Registry Number

  • 66641-38-1

Related Registry Number

  • 480-78-4 (Parent)

System Generated Number

  • 0066641381

Molecular Formulas

Molecular Formula

  • C18-H27-N-O5.Cl-H

Molecular Formula Fragments

  • C18-H27-N-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H27NO5.ClH/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20;/h4,11,13-15,22H,5-10H2,1-3H3;1H/b12-4+;/t11-,13-,14-,15-,18-;/m1./s1

InChIKey

PDTRRWDNKPZFEY-UKADVOBOSA-N

Smiles

C/C=C/1\C[C@H]([C@@](C(=O)OC[C@H]2CCN3[C@H]2[C@@H](CC3)OC1=O)(C)O)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 55mg/kg (55mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 68, Pg. 130, 1940.
monkey LDLo intravenous 20mg/kg (20mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 68, Pg. 130, 1940.
mouse LDLo intravenous 10mg/kg (10mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 68, Pg. 130, 1940.
rat LD50 intraperitoneal 160mg/kg (160mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

VASCULAR: OTHER CHANGES
Frontiers of Biology. Vol. 9, Pg. 142, 1968.
rat LDLo intravenous 60mg/kg (60mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 68, Pg. 130, 1940.