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Substance Name: Apremilast [USAN:INN]
RN: 608141-41-9
UNII: UP7QBP99PN
InChIKey: IMOZEMNVLZVGJZ-QGZVFWFLSA-N

Note

  • A PDE4 inhibitor with anti-ulcer activity.

Molecular Formula

  • C22-H24-N2-O7-S

Molecular Weight

  • 460.5046
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Phosphodiesterase Inhibitors
  • Sensory System Agents
  • Treatment of Chronic Inflammatory Conditions Including Psoriasis, Arthritis, Asthma and Cutaneous Lupus Erythematosus (CLE)
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Names and Synonyms

Name of Substance

  • Apremilast
  • Apremilast [USAN:INN]

Synonyms

  • (+)-N-(2-((1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxo- 2,3-dihydro-1H-isoindol-4-yl)acetamide
  • Apremilast
  • CC 10004
  • CC-10004
  • CC10004
  • HSDB 8221
  • Otezla
  • UNII-UP7QBP99PN

Systematic Name

  • Acetamide, N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-

Registry Numbers

CAS Registry Number

  • 608141-41-9

FDA UNII

  • UP7QBP99PN

Other Registry Number

  • 666854-78-0

System Generated Number

  • 0608141419

Structure Descriptors

InChI

1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

InChIKey

IMOZEMNVLZVGJZ-QGZVFWFLSA-N

Smiles

CCOc1cc(ccc1OC)[C@@H](CS(=O)(=O)C)N2C(=O)c3cccc(c3C2=O)NC(=O)C