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Substance Name: Bisoprolol [USAN:INN:BAN]
RN: 66722-44-9
UNII: Y41JS2NL6U
InChIKey: VHYCDWMUTMEGQY-UHFFFAOYSA-N

Note

  • A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.

Molecular Formula

  • C18-H31-N-O4

Molecular Weight

  • 325.4459
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-1 Receptor Antagonists
  • Adrenergic beta-Antagonists
  • Antihypertensive (beta-Blocker)
  • Antihypertensive Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympatholytics

Names and Synonyms

Name of Substance

  • Bisoprolol
  • Bisoprolol [USAN:INN:BAN]

MeSH Heading

  • Bisoprolol

Synonyms

  • (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol
  • (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol
  • Bisocor
  • Bisoprolol
  • Bisoprololum
  • Bisoprololum [Latin]
  • CL 297,939
  • CL 297939
  • EMD 33 512
  • HSDB 8316
  • UNII-Y41JS2NL6U

Systematic Name

  • 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-

Registry Numbers

CAS Registry Number

  • 66722-44-9

FDA UNII

  • Y41JS2NL6U

System Generated Number

  • 0066722449

Structure Descriptors

InChI

1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3

InChIKey

VHYCDWMUTMEGQY-UHFFFAOYSA-N

Smiles

CC(C)NCC(COc1ccc(cc1)COCCOC(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 143ug/kg (0.143mg/kg) CARDIAC: CHANGE IN RATE Human & Experimental Toxicology. Vol. 9, Pg. 255, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 100 deg C   EXP
log P (octanol-water) 1.87 (none)   EXP
Water Solubility 2240 mg/L 25 EST
Vapor Pressure 9.54E-09 mm Hg 25 EST
Henry's Law Constant 2.89E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.68E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.