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Substance Name: Practolol [USAN:INN:BAN]
RN: 6673-35-4
UNII: SUG9176GRW
InChIKey: DURULFYMVIFBIR-UHFFFAOYSA-N

Note

  • A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.

Molecular Formula

  • C14-H22-N2-O3

Molecular Weight

  • 266.339
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-1 Receptor Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Adrenergic (beta-Receptor)
  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Neurotransmitter Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Practolol
  • Practolol [USAN:INN:BAN]

MeSH Heading

  • Practolol

Synonyms

  • 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol
  • 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide
  • Acetamide, N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-
  • AY 21011
  • AY-21,011
  • CCRIS 1089
  • Dalzic
  • EINECS 229-712-1
  • Eraldin
  • I.C.I. 50,172
  • ICI 50172
  • N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide
  • Practolol
  • Practololo
  • Practololo [DCIT]
  • Practololum
  • Practololum [INN-Latin]
  • Praktololu
  • Praktololu [Polish]
  • Teranol
  • UNII-SUG9176GRW

Systematic Names

  • Acetamide, N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-
  • Acetanilide, 4'-(2-hydroxy-3-(isopropylamino)propoxy)-
  • Practolol

Registry Numbers

CAS Registry Number

  • 6673-35-4

FDA UNII

  • SUG9176GRW

Other Registry Number

  • 23313-50-0

System Generated Number

  • 0006673354

Structure Descriptors

InChI

1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)

InChIKey

DURULFYMVIFBIR-UHFFFAOYSA-N

Smiles

c1(ccc(NC(C)=O)cc1)OC[C@@H](CNC(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 7550mg/kg/2Y (7550mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SENSE ORGANS AND SPECIAL SENSES: CHANGES IN EXTRA-OCULAR MUSCLES: EYE

GASTROINTESTINAL: PERITONITIS
Medical Journal of Australia. Vol. 1, Pg. 44, 1975.
mouse LD50 intraperitoneal 455mg/kg (455mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 145, 1973.
mouse LD50 intravenous 67400ug/kg (67.4mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
mouse LD50 oral 3661mg/kg (3661mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
mouse LD50 subcutaneous 3357mg/kg (3357mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 intraperitoneal 540mg/kg (540mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 intravenous 130mg/kg (130mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 oral 3458mg/kg (3458mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
rat LD50 subcutaneous 7500mg/kg (7500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 126, 1973.
women TDLo oral 4mg/kg (4mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
British Medical Journal. Vol. 1, Pg. 595, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 134-136 deg C   EXP
log P (octanol-water) 0.79 (none)   EXP
Water Solubility 4470 mg/L 25 EST
Vapor Pressure 4.29E-10 mm Hg 25 EST
Henry's Law Constant 9.36E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.21E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.