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Substance Name: Alclometasone dipropionate [USAN:USP:JAN]
RN: 66734-13-2
UNII: S56PQL4N1V
InChIKey: DJHCCTTVDRAMEH-DUUJBDRPSA-N

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory (Topical)
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Reproductive Effect

Molecular Formula

  • C28-H37-Cl-O7

Molecular Weight

  • 521.0463
 

Names and Synonyms

Name of Substance

  • Alclometasone dipropionate
  • Alclometasone dipropionate [USAN:USP:JAN]

Synonyms

  • 7alpha-Chloro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
  • Aclovate
  • Alclometasone dipropionate
  • BRN 2317658
  • CCRIS 1927
  • Delonal
  • EINECS 266-464-3
  • Sch 22219
  • UNII-S56PQL4N1V
  • Vaderm

Systematic Names

  • (7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
  • 7alpha-Chloro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
  • Alclometasone dipropionate
  • Pregna-1,4-diene-3,20-dione, 7-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (7alpha,11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 66734-13-2

FDA UNII

  • S56PQL4N1V

System Generated Number

  • 0066734132

Structure Descriptors

InChI

1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1

InChIKey

DJHCCTTVDRAMEH-DUUJBDRPSA-N

Smiles

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@H]2[C@@H]3[C@H](Cl)CC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 15mg/kg (15mg/kg)   Drugs in Japan Vol. -, Pg. 70, 1990.
dog LD50 skin > 15mg/kg (15mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 70, 1990.
mouse LD50 subcutaneous 2506mg/kg (2506mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 1253, 1987.
rat LD50 oral 3593mg/kg (3593mg/kg)   Drugs in Japan Vol. -, Pg. 70, 1990.
rat LD50 skin > 75mg/kg (75mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.
rat LD50 subcutaneous 3593mg/kg (3593mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 1253, 1987.