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Substance Name: Linagliptin [USAN:INN:JAN]
RN: 668270-12-0
UNII: 3X29ZEJ4R2
InChIKey: LTXREWYXXSTFRX-QGZVFWFLSA-N

Note

  • A purine and quinazoline derivative that functions as an INCRETIN and DIPEPTIDYL-PEPTIDASE IV INHIBTOR. It is used as a HYPOGLYCEMIC AGENT in the treatment of TYPE II DIABETES MELLITUS.

Molecular Formula

  • C25-H28-N8-O2

Molecular Weight

  • 472.5502
 

Classification Codes

  • Dipeptidyl-Peptidase IV Inhibitors
  • Enzyme Inhibitors
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Hypoglycemic Agents
  • Incretins
  • Protease Inhibitors
  • Treatment of Type 2 Diabetes

Names and Synonyms

Name of Substance

  • BI 1356
  • Linagliptin [USAN:INN:JAN]

MeSH Heading

  • Linagliptin

Synonyms

  • (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
  • BI 1356
  • BI-1356
  • BS 1356 BS
  • HSDB 8204
  • Linagliptin
  • ONDERO
  • Tradjenta
  • UNII-3X29ZEJ4R2

Systematic Name

  • 1H-Purine-2,6-dione, 8-((3R)-3-amino-1-piperidinyl)-7-(2-butynyl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)-

Registry Numbers

CAS Registry Number

  • 668270-12-0

FDA UNII

  • 3X29ZEJ4R2

System Generated Number

  • 0668270120

Structure Descriptors

InChI

1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1

InChIKey

LTXREWYXXSTFRX-QGZVFWFLSA-N